557514 | Ro-31-8425 - CAS 131848-97-0 - Calbiochem

557514
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      Overview

      Replacement Information

      Tableau de caractéristiques principal

      Empirical Formula CAS #
      C₂₆H₂₄N₄O₂ · HCl 131848-97-0

      Prix & Disponibilité

      RéférenceDisponibilité Conditionnement Qté Prix Quantité
      557514-1MG
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      Interrompu(e)
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          1 mg
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          Description
          Overview A potent, cell-permeable, reversible, ATP-competitive, and selective protein kinase C inhibitor (IC50 = 15 nM for rat brain PKC). Exhibits some degree of isozyme specificity (IC50 = 8 nM for PKCα, 8 nM for PKCβI, 14 nM for PKCβII, 13 nM for PKCγ, and 39 nM for PKCε). Upregulates CD11a expression and enhances mesenchymal stromal cell adhesion under flow.
          Catalogue Number 557514
          Brand Family Calbiochem®
          Synonyms 2-[8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide, HCl, Bisindolylmaleimide X, HCl
          References
          References Levy, O., et al. 2015. Cell Reports 10, In press.
          Merritt, J.E., et al. 1997. Cell Signal 9, 53.
          Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.
          Product Information
          CAS number 131848-97-0
          ATP Competitive Y
          Form Reddish-orange solid
          Hill Formula C₂₆H₂₄N₄O₂ · HCl
          Chemical formula C₂₆H₂₄N₄O₂ · HCl
          Molar Mass 461.0
          Reversible Y
          Structure formula Image
          Applications
          Biological Information
          Primary Target PKC
          Primary Target IC50 15 nM for rat brain PKC; 8 nM for PKCα, 8 nM for PKCβI, 14 nM for PKCβII, 13 nM for PKCγ, and 39 nM for PKCε
          Purity ≥94% by HPLC
          Physicochemical Information
          Cell permeable Y
          Solubility DMSO
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R Phrase R: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S Phrase S: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze No
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          FDS

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          Certificats d'analyse

          TitreNuméro de lot
          557514

          Références bibliographiques

          Aperçu de la référence bibliographique
          Levy, O., et al. 2015. Cell Reports 10, In press.
          Merritt, J.E., et al. 1997. Cell Signal 9, 53.
          Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.
          Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision 27-February-2015 JSW
          Synonyms 2-[8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide, HCl, Bisindolylmaleimide X, HCl
          Description A potent, cell-permeable, reversible, ATP-competitive, and selective protein kinase C inhibitor (IC50 = 15 nM for rat brain PKC). Exhibits some degree of isozyme specificity (IC50 = 8 nM for PKCα, 8 nM for PKCβI, 14 nM for PKCβII, 13 nM for PKCγ, and 39 nM for PKCε). Shows slight selectivity for the conventional PKC isozymes PKCα, PKCβ, and PKCγ over the Ca2+-independent PKC isozyme PKCε. Upregulates CD11a expression and enhances mesenchymal stromal cell adhesion under flow.
          Form Reddish-orange solid
          CAS number 131848-97-0
          Molar mass 461.0
          Chemical formula C₂₆H₂₄N₄O₂ · HCl
          Structure formula
          Purity ≥94% by HPLC
          Solubility DMSO (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze No
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Irritant
          References Levy, O., et al. 2015. Cell Reports 10, In press.
          Merritt, J.E., et al. 1997. Cell Signal 9, 53.
          Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.