ABN1469-25UL Anti-Alpha-2-HS-Glycoprotein

新着ABN1469-25UL
25 µL  
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      概要

      Replacement Information
      Description
      Catalogue NumberABN1469-25UL
      DescriptionAnti-Alpha-2-HS-Glycoprotein
      Alternate Names
      • Alpha-2-Z-globulin
      • Ba-alpha-2-glycoprotein
      • Fetuin-A
      • Alpha-2 Heremans-Schmid glycoprotein
      • AHGS
      Background InformationAlpha-2-HS-glycoprotein (UniProt: P02765; also known as Alpha-2-Z-globulin, Ba-alpha-2-glycoprotein, Fetuin-A, Alpha-2 Heremans-Schmid glycoprotein, AHSG) is encoded by the AHSG (also known as FETUA, PRO2743) gene (Gene ID: 197) in human. Alpha-2-HS-glycoprotein is a serum protein of the cystatin superfamily that is synthesized by hepatocytes and is considered as a negative acute-phase reactant. It is highly expressed in various fetal tissues, but in adults it is mainly expressed in the liver. It is synthesized with a signal peptide (aa 1-18) and a connective propeptide (aa 301-340) and is subsequently cleaved into 2 chains known as Alpha-2-HS-glycoprotein chain A and Alpha-2-HS-glycoprotein chain B. The mature product is involved in multiple normal biological and pathological functions. It promotes possesses opsonic properties and is shown to be involved in endocytosis, brain development, bone resorption, regulation of insulin activity and hepatocyte growth factor (HGF) activity. Alpha-2-HS-glycoprotein also serves as a carrier protein and serves as a carrier for otherwise insoluble calcium phosphate and can act as a potent inhibitor of pathological vascular calcification. Higher levels of Alpha-2-HS-glycoprotein have been reported in gestational and type II diabetes. It is also present at higher levels in patients with endometriosis. Lower levels of Alpha-2-HS-glycoprotein are present in cancer subjects. (Ref.: Kalabay, L., et al. (2002). Eur. J. Endocrinol. 147(2); 243-248; Sindhu, S., et al. (2016). BMC Immunol. 17; 33).
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-Alpha-2-HS-Glycoprotein Antibody, Cat. No. ABN1469, is a highly specific rabbit polyclonal antibody that targets Alpha-2-HS-Glycoprotein and has been tested for use Immunohistochemistry and Western Blotting.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesWestern Blotting Analysis: A 1:500 dilution from a representative lot detected Alpha-2-HS-Glycoprotein in human retina tissue lysate.

      Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Alpha-2-HS-Glycoprotein in human liver and human bone marrow tissue sections.
      Biological Information
      ImmunogenGST/His-tagged recombinant fragment corresponding to 146 amino acids from human Alpha-2-HS-glycoprotein.
      EpitopeN-terminus
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityThis rabbit polyclonal antibody specifically detects human Alpha-2-HS-glycoprotein. It targets an epitope with in the N-terminal half.
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • AHSG
      • FETUA
      • PRO2743
      Purification MethodAffinity Purified
      UniProt Number
      Molecular Weight~55 kDa observed; 39.33 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human serum.

      Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Alpha-2-HS-Glycoprotein in human serum.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size25 µL
      Transport Information
      Supplemental Information
      Specifications