MABN2548-25UG Anti-CLN6 Antibody, clone N400/24

新着MABN2548-25UG
25 μg  
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      概要

      Replacement Information
      Description
      Catalogue NumberMABN2548-25UG
      DescriptionAnti-CLN6 Antibody, clone N400/24
      Alternate Names
      • Ceroid-lipofuscinosis neuronal protein 6
      Background InformationCeroid-lipofuscinosis neuronal protein 6 (UniProt: Q9NWW5; also known as CLN6) is encoded by the CLN6 gene (Gene ID: 54982) in human. CLN6 is a multi-pass membrane protein that is localized to endoplasmic reticulum and contributes to lysosomal function and viability of neurons. It has no homology with known proteins or functional domains, however it is highly conserved across mammalian species. Mutations in CLN6 gene have been linked to ceroid lipofuscinosis, neuronal 6 and 4A that are characterized by intracellular accumulation of autofluorescent liposomal material, seizures, dementia, visual loss, and/or cerebral atrophy. Two isoforms of CLN6 have been described that are produced by alternative splicing.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-CLN6, clone N400/24, Cat. No. MABN2548, is a highly specific mouse monoclonal antibody that targets CLN6 and has been tested for use in Immunohistochemistry (Paraffin).
      Key Applications
      • Immunohistochemistry (Paraffin)
      Biological Information
      ImmunogenRecombinant fragments corresponding to 54, 47, and 30 amino acids from non-helical regions from the N-terminal, internal, and C-terminal regions of human Ceroid-lipofuscinosis neuronal protein 6 (CLN6).
      CloneN400/24
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone N400/24 specifically detects human Ceroid-lipofuscinosis neuronal protein 6. It does not cross-react with other CLN proteins.
      IsotypeIgG2bκ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CLN6
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight35.92 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry (Paraffin) in human stomach tissue sections.

      Immunohistochemistry (Paraffin) Analysis: A 1:50 dilution of this antibody detected CLN6 in human stomach tissue sections.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications

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