MABF2103-25UG Anti-FcRH5 Antibody, clone F25

25 μg  
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      Replacement Information
      Catalogue NumberMABF2103-25UG
      DescriptionAnti-FcRH5 Antibody, clone F25
      Alternate Names
      • Fc receptor-like protein 5
      • FcR-like protein 5
      • FcRL5
      • BXMAS1
      • Fc receptor homolog 5
      • Immune receptor translocation-associated protein 2
      • IRTA2
      • CD307e
      Background InformationFc receptor-like protein 5 (UniProt: Q96RD9; also known as FcR-like protein 5, FcRL5, BXMAS1, Fc receptor homolog 5, FcRH5, Immune receptor translocation-associated protein 2, IRTA2, CD307e) is encoded by the FCRL5 (also known as FCRH5, IRTA2, UNQ503/PRO820) gene (Gene ID: 83416) in human. FcRH5 is a single-pass type I membrane protein that is expressed in marginal zone B-cells, immunoblasts, tonsillar germinal center centrocytes and in the intraepithelial and interfollicular regions of the tonsil. It is involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. It is shown to regulate BCR signaling and binds aggregated IgG and engages several of its Ig-domains to bind IgG. It is shown to be overexpressed in many lymphoma cell lines and on hairy cell leukemia cells. Serum levels of soluble FcRH5 are reported to be elevated in patients with several types of B cell tumors. FcRH5 is synthesized with a signal peptide (aa 1-15), which is cleaved off in the mature form that has a long extracellular domain (aa 16-851), a short transmembrane domain (aa 852-872), and a cytoplasmic tail (aa 873-977) that contains immunoreceptor tyrosine-based inhibitor motifs (ITIM). (Ref.: Franco, A., et al. (2013). J. Immunol. 190(11); 5739-46; Ise, T., et al. (2007). Leukemia 21(1); 169-174).
      Product Information
      PresentationPurified mouse monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationAnti-FcRH5, clone F25, Cat. No. MABF2103, is a mouse monoclonal antibody that detects Fc receptor-like protein 5 and has been tested for use in ELISA, Flow Cytometry, and Western Blotting.
      Key Applications
      • ELISA
      • Flow Cytometry
      • Western Blotting
      Application NotesFlow Cytometry Analysis: A representative lot detected FcRH5 in Flow Cytometry applications (Ise, T., et. al. (2005). Clin Cancer Res. 11(1):87-96).

      Western Blotting Analysis: A representative lot detected FcRH5 in Western Blotting applications (Ise, T., et. al. (2005). Clin Cancer Res. 11(1):87-96).

      ELISA Analysis: A representative lot detected FcRH5 in ELISA applications (Ise, T., et. al. (2005). Clin Cancer Res. 11(1):87-96).
      Biological Information
      ImmunogenFull-length FcRH5 expression plasmid followed by a boost with 293T cells transfected with FcRH5 plasmid.
      Epitopeextracellular domain
      ConcentrationPlease refer to lot specific datasheet.
      SpecificityClone F25 detects human Fc receptor-like protein 5. It targets an epitope with in the extracellular domain.
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • FCRL5
      • FCRH5
      • IRTA2
      • UNQ503/PRO820
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight106.44 kDa calculated.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in SU-DHL-5 cells.

      Flow Cytometry Analysis: 1 µg of this antibody detected FcRH5 in one million SU-DHL-5 cells .
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information