MABF2169-25UG Anti-HLA-G Antibody, clone 4H84

新着MABF2169-25UG
25 μg  
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      概要

      Replacement Information
      Description
      Catalogue NumberMABF2169-25UG
      DescriptionAnti-HLA-G Antibody, clone 4H84
      Alternate Names
      • HLA class I histocompatibility antigen alpha chain G
      • HLA G antigen
      • MHC class I antigen G
      Background InformationHLA class I histocompatibility antigen, alpha chain G (UniProt: P17693; also known as HLA G antigen, MHC class I antigen G) is encoded by the HLA-G (also known as HLA-6.0, HLAG) gene (Gene ID: 3135) in human. HLA-G is a single-pass type I membrane glycoprotein that serves as marker of extravillous cytotrophoblasts in placenta and plays a central role in molecule maternal tolerance of the semiallogeneic fetus. It is involved in the presentation of foreign antigens to the immune system. HLA-G is a heterodimer of an alpha chain and a beta chain. Severn different isoforms of HLA-G have been described that are produced by alternative splicing and their distribution is temporally affected during pregnancy in placenta and fetal tissues. HLA-G expression has been reported in renal cell carcinoma where it is exclusively restricted to tumor cells. Its expression is thought to be involved in the impairment of the anti-tumor immunity or resistance to immunotherapeutic agents. HLA-G is synthesized with a signal peptide (aa 1-24), which is subsequently cleaved off to generate the mature form, which contains an extracellular domain (aa 25-308), a transmembrane domain (aa 309-332), and a short cytoplasmic tail (aa 333-338).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-HLA-G, clone 4H84, Cat. No. MABF2169, is a mouse monoclonal antibody that detects HLA class I histocompatibility antigen, alpha chain G and has been tested for use in ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), and Western Blotting.
      Key Applications
      • ELISA
      • Flow Cytometry
      • Immunohistochemistry (Paraffin)
      • Western Blotting
      Application NotesImmunohistochemistry (Paraffin) Analysis: A 1:50 dilution from a representative lot detected HLA-G in human spleen tissue sections.

      Immunohistochemistry (Paraffin) Analysis: A representative lot detected HLA-G in Immunohistochemistry applications (Tabata, T., et. al. (2012). Am J Pathol. 181(5):1540-59; Menier, C., et. al. (2003). Hum Immunol. 64(3):315-26; Ibrahim, E.C., et. al. (2003). Am J Pathol. 162(2):501-8; Tabata, T., et. al. (2016). Cell Host Microbe. 20(2):155-66; McMaster, M., et. al. (1998). J Immunol. 160(12):5922-8).

      Western Blotting Analysis: A representative lot detected HLA-G in Western Blotting applications (Paul, P., et. al. (1999). Cancer Res. 59(8):1954-60; McMaster, M., et. al. (1998). J Immunol. 160(12):5922-8).

      ELISA Analysis: A representative lot detected HLA-G in ELISA applications (McMaster, M., et. al. (1998). J Immunol. 160(12):5922-8).

      Flow Cytometry Analysis: A representative lot detected HLA-G in Flow Cytometry applications (Menier, C., et. al. (2003). Hum Immunol. 64(3):315-26).
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to 23 amino acids from the N-terminal region of Human MHC class I antigen G. The immunogen sequence is conserved in all isoforms.
      Clone4H84
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 4H84 specifically detects human HLA-G. It recognizes an epitope with in 23 amino acids from the alpha1 region of all HLA-G isoforms.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • HLA-G
      • HLA-6.0
      • HLAG
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight38.22 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry (Paraffin) in human placenta tissue sections.

      Immunohistochemistry (Paraffin) Analysis: A 1:50 dilution of this antibody detected HLA-G in human placenta tissue sections.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications

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