MABS1998-100UG | Anti-HPa3 Antibody, clone HIC3-2D12

100 μg  
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      Replacement Information


      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H IH(P), FC M Purified Monoclonal Antibody
      Catalogue NumberMABS1998-100UG
      DescriptionAnti-HPa3 Antibody, clone HIC3-2D12
      Alternate Names
      • Non-beta endocrine cells
      Background InformationPancreas performs both the endocrine and the exocrine function. The bulk of pancreas is composed of exocrine cells that produce digestion enzymes which are released into ducts to be emptied into the duodenum. The endocrine pancreas is composed of islets of Langerhans that produce hormones. At least five distinct endocrine cell types have been identified in the endocrine pancreas, each producing a different hormone. Beta cells produce insulin, which is considered as an anabolic hormone and regulates blood glucose levels and is also involved in fat and protein synthesis. Alpha cells produce glucagon that acts when blood glucose levels are low. Ductal cells of pancreas form the epithelial lining of the branched tubes that deliver digestive enzymes into the duodenum. They also secrete bicarbonate to neutralize acidic contents coming in from stomach. Duct cells may contribute up to 10% of all pancreatic cells. Acinar cells function as a unit of the exocrine pancreas and they synthesize, store, and secrete digestive enzymes (lipase, alpha amylase, trypsin, and chymotrypsin), which under normal physiological conditions are activated only after reaching the duodenum. Premature activation of these enzymes within pancreatic acinar cells can lead to acute pancreatitis. Clone HIC-2D2 can be used to mark all non-beta endocrine cell types in human pancreatic tissue. (Ref.: Dorrell, C., et al. (2008). Stem Cell Research (2008). 1(3); 183-194; Grapin-Botton, A (2005). Int. J. Biochem. Cell Biol. 37(3); 504-510; Leung, PS (2006). Int. J. Biochem. Cell Biol. 38(7); 1024-1030).
      Product Information
      PresentationPurified mouse monoclonal antibody IgM in PBS with 0.05% sodium azide.
      ApplicationAnti-HPa3, clone HIC3-2D12, Cat. No. MABS1998, is a mouse monoclonal antibody that detects human pancreatic non-beta endocrine cells and has been tested for use in Flow Cytometry and Immunohistochemistry (Paraffin).
      Key Applications
      • Immunohistochemistry (Paraffin)
      • Flow Cytometry
      Application NotesFlow Cytometry Analysis: A representative lot detected HPa3 in Flow Cytometry applications (Dorrell, C., et. al. (2008). Stem Cell Res. 1(3):183-94; Bramswig, N.C., et. al. (2013). J Clin Invest. 123(3):1275-84; Dorrell, C., et. al. (2016). Nat Commun. 7:11756).
      Biological Information
      ImmunogenHuman pancreatic islets enriched in non-beta endocine cells.
      ConcentrationPlease refer to lot specific datasheet.
      SpecificityClone HIC3-2D12 detects human pancreatic non-beta endocrine cells.
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Purification MethodPurified by ion-exchange chromatography
      UniProt Number
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry (Paraffin) in human pancreatic tissue sections.

      Immunohistochemistry (Paraffin) Analysis: A 1:50 dilution of this antibody detected HPa3 in human pancreatic tissue sections.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information