MABF342 | Anti-IL-6 (human) Antibody, FITC, clone MQ2-13A5

MABF342
100 tests  
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      概要

      Replacement Information

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      主要スペック表

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H FC R FITC Monoclonal Antibody
      Description
      Catalogue NumberMABF342
      DescriptionAnti-IL-6 (human) Antibody, FITC, clone MQ2-13A5
      Alternate Names
      • Interleukin-6
      • IL-6
      • B-cell stimulatory factor 2
      • BSF-2
      • CTL differentiation factor
      • CDF
      • Hybridoma growth factor
      • Interferon beta-2
      • IFN-beta-2
      • IL6
      Background InformationInterleukin-6 (IL-6) is a pro-inflammatory cytokine that seems to be involved in the late stages of CTL generation. Other biological functions also include amplification and the inflammatory response. Combination therapies including IL-6 have been shown to have positive effects on specific malignant tumor types. The accumulation of IL-6 in the CNS is usually detrimental and can contribute to pathology of CNS diseases. IL-6 signaling is negatively regulated by TGF-beta, which down regulates STAT1, STAT3 and ICAM-1 expression. IL-6 expression has been linked to inflammatory bowel disease (IBD) and is also the primary clinical target for IBD. Clinical use of an antibody for the IL-6 receptor (IL-6R) has been promising in treating rheumatoid arthritis, systemic juvenile idiopathic arthritis and Castleman’s disease.
      References
      Product Information
      FormatFITC
      PresentationPurified rat conjugate antibody in buffer containing PBS (pH 7.2) with up to 0.1% sodium azide and 0.2% (w/v) BSA.
      Applications
      ApplicationDetect IL-6 using this rat monoclonal antibody, Anti-IL-6 (human) Antibody, FITC & clone MQ2-13A5 validated for use in Flow Cytometry.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenCOS-7- expressed, recombinant human IL-6
      CloneMQ2-13A5
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRat
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • IL6
      • IFNB2
      Purification MethodAffinity
      UniProt Number
      Molecular Weight24 kDa calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceThe antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions. The solution is free of unconjugated FITC and unconjugated antibody.

      Flow Cytometry Analysis: 5 μL of this antibody detected IL-6 in one million LPS-stimulated human peripheral blood monocytes.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsThe antibody solution should be stored undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
      Packaging Information
      Material Size100 tests
      Transport Information
      Supplemental Information
      Specifications

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      カテゴリー

      Life Science Research > Antibodies and Assays > Primary Antibodies