MAB1399Z-I-100UG | Anti-Integrin αX Antibody, clone N418 Antibody, azide free

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100 μg  
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      概要

      Replacement Information

      主要スペック表

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M IHC, FC, IP AHm Purified Monoclonal Antibody
      Description
      Catalogue NumberMAB1399Z-I-100UG
      DescriptionAnti-Integrin αX Antibody, clone N418 Antibody, azide free
      Alternate Names
      • Integrin alpha-X
      • CD11 antigen-like family member C
      • Leukocyte adhesion glycoprotein p150
      • 95 alpha chain
      • Leukocyte adhesion receptor p150
      • 95
      • CD11c
      Background InformationIntegrin alpha-X (UniProt: Q9QXH4; also known as CD11 antigen-like family member C, Leukocyte adhesion glycoprotein p150,95 alpha chain, Leukocyte adhesion receptor p150,95, CD11c) is encoded by the Itgax gene (gene ID: 16411) in murine species. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. CD11c is a single-pass type I membrane protein. It has an extracellular domain (aa 20-1116), a transmembrane domain (aa 1117-1137), and a cytoplasmic domain (aa 1138-1169). It is synthesized with a signal peptide (aa 1-19), which is subsequently cleaved off in the mature form. Low levels of CD11c are expressed on human granulocytes and monocytes, and higher expression levels are observed on macrophages, dendritic cells and hairly cell leukemias. CD11c associates with beta-2 subunit in a non-covalent manner and then serves as a receptor for fibrinogen where it recognizes the sequence G-P-R. CD11c is shown to mediate cell-cell interaction during inflammatory responses and is important in monocyte adhesion and chemotaxis. Clone N418 is known to recognize an epitope on the p150 alpha chain. (Ref.: Metlay, JP et al. (1990). J. Exp. Med. 171(5); 1753-1771).
      References
      Product Information
      FormatPurified
      PresentationPurified armenian hamster monoclonal antibody IgG in PBS without preservatives.
      Applications
      ApplicationAnti-Integrin X, clone N418, azide free, Cat. No. MAB1399Z-I, is an armenian hamster monoclonal antibody that detects Integrin alpha-X and has been tested for use in Immunohistochemistry, Flow Cytometry, and Immunoprecipitation.
      Key Applications
      • Immunohistochemistry
      • Flow Cytometry
      • Immunoprecipitation
      Application NotesImmunoprecipitation Analysis: A representative lot detected Integrin X in Immunoprecipitation applications (Metlay, J.P., et. al. (1990). J Exp Med. 171(5):1753-71).

      Immunohistochemistry Analysis: A representative lot detected Integrin X in Immunohistochemistry applications (Tan, C.S.E., et. al. (2017). PLoS Pathog. 13(4):e1006311; Roland, C.L., et. al. (2009). Mol Cancer Ther. 8(7):1761-71; Metlay, J.P., et. al. (1990). J Exp Med. 171(5):1753-71).

      Flow Cytometry Analysis: A representative lot detected Integrin X in Flow Cytometry applications (Metlay, J.P., et. al. (1990). J Exp Med. 171(5):1753-71; Granucci, F., et. al. (1997). J Immunol. 159(4):1794-99; Cervantes-Barragan, L., et. al. (2007). Blood. 109(3):1131-37).
      Biological Information
      ImmunogenMouse spleen dendritic cells.
      CloneN418
      ConcentrationPlease refer to lot specific datasheet.
      HostArmenian Hamster
      SpecificityClone N418 is a mouse monoclonal antibody that detects integrin alpha-X in murine tissue.
      IsotypeIgG
      Species Reactivity
      • Mouse
      Species Reactivity NoteMouse.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Itgax
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight129.15 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in mouse spleen frozen tissue sections.

      Immunohistochemistry Analysis: A 1:25 dilution of this antibody detected Integrin X in mouse spleen frozen tissue sections.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications