MABF1986 | Anti-NKR-P1G Antibody, clone ADA3

MABF1986
200 µL  
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      概要

      Replacement Information

      主要スペック表

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R FC, IP AHm Purified Monoclonal Antibody
      Description
      Catalogue NumberMABF1986
      DescriptionAnti-NKR-P1G Antibody, clone ADA3
      Alternate Names
      • Killer cell lectin-like receptor subfamily B member 1
      • Immunoreceptor NKR-P1E
      • Killer cell lectin-like receptor subfamily B member 1G
      • Natural killer cell surface protein NKR-P1G
      • Natural killer lectin-like receptor 1E
      Background InformationKiller cell lectin-like receptor subfamily B member 1 (UniProt: Q0ZUP0; also known as Immunoreceptor NKR-P1E, Killer cell lectin-like receptor subfamily B member 1G, Natural killer cell surface protein NKR-P1G, Natural killer lectin-like receptor 1E) is encoded by the Klrb1 (also known as Klrb1d, Klrb1g, Klrb6, Nkrp1e, Nkrp1g) gene (Gene ID: 689817) in rat. NKR-P1G is a single-pass type II membrane protein with a cytoplasmic domain (aa 1-42), a helical domain (aa 43-63), and an extracellular domain (aa 64-214). NKR-P1G is expressed by subsets of lymphocytes with highest prevalence in gut and liver mucosa. The number of NKR-P1G+ cells are shown to increase with age and its expression level is modulated by cytokines, with an increase induced by inflammatory cytokines. It is shown to be mainly expressed by Ly49s3+ cells. It is reported to inhibit cytotoxicity and calcium responses in IL-2-activated NK cells. NKR-P1G is a potent inhibitory receptor for a panel of Clr ligands. The intracellular domain of NKR-P1G contains an immunoreceptor tyrosine-based inhibitory motif that is phosphorylated by Src-kinases upon activation. This allows recruitment of phosphotyrosine phosphatases, which in turn negatively regulates the signaling cascades that is essential for cytotoxicity and cytokine production. (Ref.: Kveberg, L et al (2015). Eur J Immunol. 45(2); 501-512).
      References
      Product Information
      FormatPurified
      PresentationPurified Armenian hamster monoclonal antibody IgG in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-NKR-P1G, clone ADA3, Cat. No. MABF1986 is an Armenian hamster monoclonal antibody that detects NKG-P1G and has beent tested for use in Flow Cytometry and Immunoprecipitation.
      Key Applications
      • Flow Cytometry
      • Immunoprecipitation
      Application NotesImmunoprecipitation Analysis: A representative lot detected NKR-PIG in Immunoprecipitation applications (Kveberg, L., et. al. (2015). Eur J Immunol. 45(2):501-12).

      Flow Cytometry Analysis: A representative lot detected NKR-PIG in Flow Cytometry applications (Kveberg, L., et. al. (2015). Eur J Immunol. 45(2):501-12).
      Biological Information
      ImmunogenChinese hamster ovary (CHO) cells stably transfected with FLAG-tagged extracellular portion of NKR-P1G.
      Epitopeextracellular domain
      CloneADA3
      ConcentrationPlease refer to lot specific datasheet.
      HostArmenian Hamster
      SpecificityClone ADA3 is an Armenian hamster monoclonal antibody that detects Killer cell lectin-like receptor subfamily B member 1 (NKR-P1G) in rat. It targets an epitope within the extracellular domain.
      IsotypeIgG
      Species Reactivity
      • Rat
      Species Reactivity NoteRat.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Klrb1
      • Klrb1d
      • Klrb1g Klrb6
      • Nkrp1e
      • Nkrp1g
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight23.96 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in Ltk (mouse fibroblast) cells stably transfected with FLAG-tagged rat NKR-P1G.

      Flow Cytometry Analysis: 1 µg of this antibody detected NKR-P1G in Ltk (mouse fibroblast) cells stably transfected with FLAG-tagged rat NKR-P1G.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications