MABC117 Anti-Podoplanin Antibody, clone NZ1.2

MABC117
100 µL  
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      概要

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      主要スペック表

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, IHC R Purified Monoclonal Antibody
      Description
      Catalogue NumberMABC117
      DescriptionAnti-Podoplanin Antibody, clone NZ1.2
      Alternate Names
      • Aggrus
      • Glycoprotein 36
      • Gp36
      • PA2.26 antigen
      • T1-alpha
      • T1A
      Background InformationHuman podoplanin (T1alpha-2, aggrus and gp36) is a 38 kDa type-1 transmembrane glycoprotein that consists of 162 amino acids, nine of which form the intracellular domain. The highly O-glycosylated extracellular domain contains a sialic acid that is linked to an alpha-2,3 galactose, which forms the main part of the protein’s carbohydrate moieties. It is expressed in a select variety of human tissues and organs, and is also found in lymphatic, but not blood vessel endothelium. While its mode of action remains unclear, podoplanin is suggested to play a critical role in several physiological processes and conditions such as cell migration, cytoskeleton organization, tissue development, and tissue repair, as well as in carcinogenesis and tumor cell invasion.
      References
      Product Information
      FormatPurified
      Control
      • Human lung tissue lysate.
      PresentationPurified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-Podoplanin Antibody, clone NZ1.2 is an antibody against Podoplanin for use in WB, IH.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:300 dilution from a representative lot detected Podoplanin in human lung adenocarcinoma and colorectal tissue.
      Biological Information
      ImmunogenProtein sequence corresponding to the PLAG domain of human Podoplanin.
      EpitopePLAG Domain
      CloneNZ1.2
      HostRat
      SpecificityThis antibody detects Podoplanin at the PLAG domain.
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified.
      Gene Symbol
      • PDPN
      • GP36
      • GP36
      • PSEC0003
      • PSEC0025
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels.

      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Cell projection > filopodium membrane; Single-pass type I membrane protein. Cell projection > lamellipodium membrane; Single-pass type I membrane protein. Cell projection › microvillus membrane; Single-pass type I membrane protein. Cell projection > ruffle membrane; Single-pass type I membrane protein. Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles.

      TISSUE SPECIFICITY: Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas.
      Molecular Weight~25 kDa observed.
      4 isoforms are produced by alternative splicing, at molecular weights of ~17 kDa (isoform 1), ~18 kDa (isoform 2), ~25 kDa (isoform 3), and ~25 kDa (isoform 4).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in human lung tissue lysate.

      Western Blot Analysis: A 1:2,000 dilution of this antibody detected Podoplanin in 10 µg of human lung tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      (M)SDS

      タイトル

      英語版製品安全データシート((M)SDS) 

      試験成績書(CoA)

      タイトルロット番号
      Anti-Podoplanin, clone NZ1.2 - 21421912142191
      Anti-Podoplanin, clone NZ1.2 - 23093272309327
      Anti-Podoplanin, clone NZ1.2 - NRG1941032NRG1941032
      Anti-Podoplanin, clone NZ1.2 -25255662525566
      Anti-Podoplanin, clone NZ1.2 -27968292796829
      Anti-Podoplanin, clone NZ1.2 -28106152810615
      Anti-Podoplanin, clone NZ1.2 -28451032845103
      Anti-Podoplanin, clone NZ1.2 Monoclonal Antibody2911995
      Anti-Podoplanin, clone NZ1.2 Monoclonal Antibody3084594
      Anti-Podoplanin, clone NZ1.2 Monoclonal Antibody2926057

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      カテゴリー

      Life Science Research > Antibodies and Assays > Primary Antibodies