MABT546-25UL Anti-Troponin I Antibody, clone 5C11.1

新着MABT546-25UL
25 µL  
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      概要

      Replacement Information

      主要スペック表

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB M Purified Monoclonal Antibody
      Description
      Catalogue NumberMABT546-25UL
      DescriptionAnti-Troponin I Antibody, clone 5C11.1
      Alternate Names
      • Cardiac Troponin I
      Background InformationTroponin I, cardiac muscle (UniProt: P19429; also known as Cardiac troponin I) is encoded by the TNNI3 (also known as TNNC1) gene (Gene ID: 7137) in human. Troponin is a complex that regulates the contraction of skeletal muscle, It consists of 3 subunits known as C, T, and I, which are located periodically along the thin filament of the myofibrils. Troponin C (TnC) binds calcium ions, Troponin I is the inhibitory subunit of troponin that inhibits actomyosin ATPase and Troponin T binds to tropomyosin. It also confers calcium-sensitivity to actomyosin ATPase. Amino acids region 32-79 of Troponin I is involved in binding to TnC and region 129-149 is involved in binding to both TnC and actin. It is thought that troponin I acts as a switch, by moving away from actin toward troponin C, following Ca2+ binding to TnC. Cardiac muscle Troponin I has 31 amino acid residues on its N-terminal that are not present in the skeletal muscle form. Hence, cardiac specificity of this isoform is shown to offer accuracy in diagnosis in patients with acute or chronic skeletal muscle injury. Mutation in TNNI3 gene are reported to result in multiple types of cardiomyopathies that can result in premature death. (Ref.: Li, H-C., and Fajer, PG (1998). Biochemistry 37(19); 6628-6635).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-Troponin I, clone 5C11.1, Cat. No. MABT546, is a mouse monoclonal antibody that detects Troponin I and has been tested for use in Western Blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to 14 amino acids from the C-terminal region of human Troponin I.
      Clone5C11.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 5C11.1 specifically detects Tropinin I in multiple species. It targets an epitope with in 14 amino acids from the C-terminal region.
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with Rat, Bovine, Mouse, Chicken based on 100% sequence homology.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TNNI3
      • TNNC1
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight~22 kDa observed; 24.00 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human skeletal muscle tissue lysate.

      Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Troponin I in human skeletal muscle tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size25 µL
      Transport Information
      Supplemental Information
      Specifications