MABS1925-100UG Anti-carboxypeptidase M Antibody, clone 7F9

100 μg  
Minimum Quantity needs to be mulitiple of
弊社照会 詳細を表示 
    Remaining : Will advise
      Remaining : Will advise
      Contact Customer Service





      Replacement Information
      Catalogue NumberMABS1925-100UG
      DescriptionAnti-carboxypeptidase M Antibody, clone 7F9
      Alternate Names
      • CPM
      • CP-M
      Background InformationCarboxypeptidase M (UniProt: D4A9Q5; also known as CPM) is encoded by the Cpm gene (Gene ID: 314855) in rat. Rat CPM a glycosylphosphatidylinositol (GPI) anchored metallo-carboxypeptidase that cleaves basic carboxyl-terminal amino acids from various peptides at neutral pH. Rat CPM is synthesized with a signal peptide (aa 1-17), which is subsequently cleaved off to generate the mature form. The mature CPM displays high specificity and cleaves only C-terminal arginine or lysine residues in a variety of peptide substrates. It is shown to be expressed in the lung and placenta at high levels. Its expression is detected in alveolar cells lacking T1alpha, a type I cell marker protein found in adult lung. Carboxypeptidase M also serves as a macrophage differentiation marker, which is preferentially induced in epithelioid cells of all granuloma types studied, but not in resting macrophages. Hence, it can be employed for detection of minute granuloma even in the presence of non-granulomatous macrophages. Clone 7F9 recognizes CPM expressed in late embryonic rat lung to postnatal day 1. (Ref.: Fujiwara, N., et al. (2007), Respirology 12(1); 54-62; Tsakiris, I., et al. (2012). Lab. Invest. 92(3); 345-361).

      Product Information
      PresentationPurified mouse monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationAnti-carboxypeptidase M, clone 7F9, Cat. No. MABS1925, is a mouse monoclonal antibody that detects Carboxypeptidase M and has been tested for use in Immunofluorescence, Immunohistochemistry, Immunoprecipitation, and Western Blotting.
      Key Applications
      • Immunofluorescence
      • Immunohistochemistry
      • Immunoprecipitation
      • Western Blotting
      Application NotesWestern Blotting Analysis: A representative lot detected carboxypeptidase M in Western Blotting applications (Fujiwara, N., et. al. (2007). Respirology. 12(1):54-62).

      Immunoprecipitation Analysis: A representative lot immunoprecipitated carboxypeptidase M in Immunoprecipitation applications (Fujiwara, N., et. al. (2007). Respirology. 12(1):54-62).

      Immunohistochemistry Analysis: A representative lot detected carboxypeptidase M in Immunohistochemistry applications (Fujiwara, N., et. al. (2007). Respirology. 12(1):54-62).
      Biological Information
      ImmunogenMembrane fraction of E18.5 embryonic rat lung.
      Epitopeextracellular domain
      ConcentrationPlease refer to lot specific datasheet.
      SpecificityClone 7F9 specifically detects carboxypeptidase M in rat tissues.
      Species Reactivity
      • Rat
      Species Reactivity NoteRat.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Cpm
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight50.32 kDa calculated.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunofluorescence in E19 rat embryo tissue sections.

      Immunofluorescence Analysis: A 1:25 dilution of this antibody detected carboxypeptidase M in E19 rat embryo tissue sections.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information