531067 | HSP70 Inhibitor, PES-Cl - Calbiochem

531067
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      概要

      Replacement Information

      主要スペック表

      Empirical Formula
      C₈H₆ClNO₂S

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      5.31067.0001
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          ガラスビン 10 mg
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          Description
          OverviewA cell-permeable chlorophenylethynylsulfonamide compound that binds directly to the substrate-binding domain of heat shock protein 70 (HSP70) and disrupts its interaction with client proteins. Impairs the activity of the anaphase promoting complex/cyclosome (APC/C) in cell-free extracts. Arrests cell cycle at G2/M phase and preferentially induces genomic instability in cancer cells (IC50 = 2 to 5 µM in melanoma cell lines). Exhibits much reduced toxicity in non-transformed cells (IC50 >100 µM in primary melanocytes). Induces apoptosis and inhibits autophagy as evidenced by increased p62SQSTM1 and LC3 accumulation. Also, shown to extend life in murine models of pre-B cell lymphoma.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number531067
          Brand Family Calbiochem®
          SynonymsHeat Shock Protein 70 Inhibitor
          References
          ReferencesBalaburski, G., et al. 2013. Mol. Cancer Res. 11, 1.
          Budina-Kolomets, A. et al. 2013. Cancer Biol. Ther. 15, 194.
          Product Information
          FormWhite powder
          Hill FormulaC₈H₆ClNO₂S
          Chemical formulaC₈H₆ClNO₂S
          ReversibleY
          Applications
          Biological Information
          Primary TargetHSP70
          Primary Target IC<sub>50</sub>2-5 µ
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          (M)SDS

          タイトル

          英語版製品安全データシート((M)SDS) 

          参考資料

          参考資料の概要
          Balaburski, G., et al. 2013. Mol. Cancer Res. 11, 1.
          Budina-Kolomets, A. et al. 2013. Cancer Biol. Ther. 15, 194.
          データシート

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision29-August-2014 JSW
          SynonymsHeat Shock Protein 70 Inhibitor
          DescriptionA cell-permeable chlorophenylethynylsulfonamide compound that binds directly to the substrate-binding domain of heat shock protein 70 (HSP70) and disrupts its interaction with client proteins. Impairs the activity of the anaphase promoting complex/cyclosome (APC/C) in cell-free extracts. Arrests cell cycle at G2/M phase and preferentially induces genomic instability in cancer cells (IC50 = 2 to 5 µM in melanoma cell lines). Exhibits much reduced toxicity in non-transformed cells (IC50 >100 µM in primary melanocytes). Induces apoptosis and inhibits autophagy as evidenced by increased p62SQSTM1 and LC3 accumulation. Also, shown to extend life in murine models of pre-B cell lymphoma.
          FormWhite powder
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₈H₆ClNO₂S
          Purity≥98% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesBalaburski, G., et al. 2013. Mol. Cancer Res. 11, 1.
          Budina-Kolomets, A. et al. 2013. Cancer Biol. Ther. 15, 194.