MAB5460-25UL | MOUSE ANTI-NKX2.1 MONOCLONAL ANTIBODY

MAB5460-25UL
25 µL  
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      Description
      Catalogue NumberMAB5460-25UL
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionMOUSE ANTI-NKX2.1 MONOCLONAL ANTIBODY
      Alternate Names
      • TTF-1
      • Thyroid Transcription Factor-1
      References
      Product Information
      FormatAscites
      PresentationAscites fluid. Liquid. Contains no preservative.
      Applications
      ApplicationThis Anti-Nkx2.1 Antibody is validated for use in WB, IH(P) for the detection of Nkx2.1.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesWestern blot. The antibody reacts with a 40 kDa band in immunoblots of nuclear extracts or whole cell lysates from the Nkx2.1 positive cell lines MLE15, H441-4, H345 and rat type II pmeumocyte cells.

      Immunohistochemistry. The antibody can be used on formalin-fixed paraffin embedded tissue. Heat induced epitope retrieval is recommended.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenRecombinant rat Nkx2.1.
      Clone8G7-G3-1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityNkx2.1 (Thyroid Transcription Factor-1, TTF-1).
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • NKX2-1
      • BCH
      • TEBP
      • TITF1
      • TTF1
      • NKX2.1
      • NK-2
      • TTF-1
      • BHC
      • NKX2A
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P43699 # Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis.
      SIZE: 371 amino acids; 38596 Da
      SUBCELLULAR LOCATION: Nucleus.
      TISSUE SPECIFICITY: Thyroid and lung.
      PTM: Phosphorylated on serine residues (By similarity).
      DISEASE: SwissProt: P43699 # Defects in TITF1 are the cause of benign hereditary chorea (BHC) [MIM:118700]; also known as hereditary chorea without dementia. BHC is an autosomal dominant movement disorder. The early onset of symptoms (usully before the age of 5) and the observation that in some BHC families the symptoms tend to decrease in adulthood suggests that the disorder results from a developmental disturbance of the brain. BHC is non-progressive and patients have normal or slightly below normal intelligence. There is considerable inter- and intrafamilial variability, including dysarthria, axial distonia and gait disturbances. & Defects in TITF1 are the cause of choreoathetosis, hypothyroidism, and neonatal respiratory distress (CHNRD) [MIM:610978]. This syndrome include neurological, thyroid, and respiratory problems.
      SIMILARITY: SwissProt: P43699 ## Belongs to the NK-2 homeobox family. & Contains 1 homeobox DNA-binding domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceTested
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size25 µL
      Transport Information
      Supplemental Information
      Specifications

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