239764 | Cycloheximide, High Purity - CAS 66-81-9 - Calbiochem

239764
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      Overview

      Replacement Information

      主要スペック表

      実験式 CAS番号
      C₁₅H₂₃NO₄66-81-9

      価格&在庫状況

      カタログ番号在庫状況 包装 Qty/Pk 価格 数量
      239764-100MGCN
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          100 mg
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          239764-1GMCN
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              1 gm
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              説明
              概要 Antifungal antibiotic that inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFKBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T cell hybridomas, Burkitt’s lymphoma cells, and a variety of other cell types including rodent macrophages. However, it inhibits DNA cleavage in rat thymocytes treated with Thapsigargin (Cat. No. 586005), methylprednisolone, and Ionomycin (Cat. Nos. 407950 and 407952). Rapidly destroyed in alkaline solutions. Also available as a 300 mM solution in DMSO (Cat. No. 508739).
              カタログ番号 239764
              ブランドファミリー Calbiochem®
              参考資料
              参考資料 Christner, C., et al. 1999. J. Med. Chem. 42, 3615.
              Lu, Q., et al. 1996. Arch. Biochem. Biophys. 334, 175.
              Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
              Cotter, T.G., et al. 1992. Anticancer Res. 12, 773.
              Takano, Y.S., et al. 1991. J. Pathol. 163, 329.
              Waring, P. 1990. J. Biol. Chem. 265, 14476.
              製品情報
              CAS番号 66-81-9
              形状 White solid
              Hill方式 C₁₅H₂₃NO₄
              化学式 C₁₅H₂₃NO₄
              Molar Mass 281.3
              構造式のイメージ
              アプリケーション
              生体情報
              一次標的 hFKBP12
              一次標的のKi 3.4 µM
              純度 ≥98% by HPLC
              物理化学情報
              溶解性 EtOH or MeOH
              寸法
              材料情報
              有害性情報
              GHSに関する安全性情報
              RTECS MA4375000
              安全性情報
              R フレーズ R: 28-40-51/53-61




              S フレーズ S: 45-53-61



              製品使用について
              保管および輸送に関する情報
              輸送コード Ambient Temperature Only
              毒性 Highly Toxic & Carcinogenic / Teratogenic
              有害物質注意: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
              保管 +15°C to +30°C
              冷凍しないでください。 No
              特記事項欄 Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 6 weeks at 4°C, pH 3-5.
              パッケージ情報
              輸配送情報
              補足情報
              規格

              Documentation

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              試験成績書(CoA)

              タイトルロット番号
              239764

              参考資料

              参考資料の概要
              Christner, C., et al. 1999. J. Med. Chem. 42, 3615.
              Lu, Q., et al. 1996. Arch. Biochem. Biophys. 334, 175.
              Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
              Cotter, T.G., et al. 1992. Anticancer Res. 12, 773.
              Takano, Y.S., et al. 1991. J. Pathol. 163, 329.
              Waring, P. 1990. J. Biol. Chem. 265, 14476.

              カタログ

              タイトル
              Tools and Tips for Analyzing Apoptosis

              引用

              Title
            • Hui Zeng, et al. (2005) Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. American Journal of Physiology Gastrointestinal and Liver Physiology in press,.
            • データシート

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              改訂 29-April-2008 RFH
              説明 Antifungal antibiotic that does not inhibit several species of pathogenic bacteria at 100 µg/ml. Inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFkBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T-cell hybridomas, Burkitt's lymphoma cells, and a variety of other cell types, including rodent macrophages. Inhibits DNA cleavage in rat thymocytes treated with thapsigargin, methylprednisolone, and ionomycin. Rapidly destroyed in alkaline solutions.
              形状 White solid
              CAS番号 66-81-9
              RTECS MA4375000
              モル質量 281.3
              化学式 C₁₅H₂₃NO₄
              構造式
              純度 ≥98% by HPLC
              溶解性 Chloroform, Ethanol, and Methanol
              保管 +15°C to +30°C
              Do Not Freeze No
              Special Instructions Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 6 weeks at 4°C, pH 3-5.
              毒性 Highly Toxic & Carcinogenic / Teratogenic
              メルク・インデックス 14, 2728
              参考資料 Christner, C., et al. 1999. J. Med. Chem. 42, 3615.
              Lu, Q., et al. 1996. Arch. Biochem. Biophys. 334, 175.
              Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
              Cotter, T.G., et al. 1992. Anticancer Res. 12, 773.
              Takano, Y.S., et al. 1991. J. Pathol. 163, 329.
              Waring, P. 1990. J. Biol. Chem. 265, 14476.
              引用
            • Hui Zeng, et al. (2005) Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. American Journal of Physiology Gastrointestinal and Liver Physiology in press,.