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852070 | Fmoc-Thr(PO(OBzl)OH)-OH

852070
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Hill FormulaMolar Mass
      175291-56-2C₂₆H₂₆NO₈P511.47 g/mol

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      8520700001
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          Glass bottle 1 g
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          8520700005
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              Glass bottle 5 g
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              Description
              Catalogue Number852070
              Replaces04-12-1155
              Brand Family Novabiochem®
              Alternate Names
              • N-α-Fmoc-O-benzyl-L-phosphothreonine
              Background InformationAn excellent building block for the preparation of phosphothreonine-containing peptides [1, 2]. This derivative can be introduced using standard activation methods, such as PyBOP® and TBTU. The monoprotected phosphothreonine residue once incorporated is stable to piperidine. Using this reagent, even peptides containing multiple phosphorylation sites can be prepared efficiently by standard Fmoc SPPS methods [1].

              A paper describes the use of this derivative in the preparation of phospholamban [3], a 52 residue peptide containing both phosphoserine and phosphothreonine.

              The product number for this product was previously 04-12-1155.

              To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
              References
              Product Information
              CAS number175291-56-2
              Hill FormulaC₂₆H₂₆NO₈P
              Molar Mass511.47 g/mol
              HS Code2924 29 70
              Structure formula Image
              Applications
              ApplicationFmoc-Thr(PO(OBzl)OH)-OH Novabiochem®. CAS 175291-56-2, molar mass 511.47 g/mol.
              Biological Information
              Physicochemical Information
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Storage class10 - 13 Other liquids and solids
              WGKWGK 2 water endangering
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              StorageStore at -15°C to -25°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications
              Colour (visual)white to slight yellow to beige
              Appearance of substance (visual)powder
              Identity (IR)passes test
              Optical rotation α 25/D (c=1 in DMF)-6.5 - -3.5 °
              Purity (TLC(CMA1))≥ 98 %
              Assay (HPLC, area%)≥ 98.0 % (a/a)
              Solubility (1 mmole in 2 ml DMF)clearly soluble
              Assay (acidimetric)≥ 90.0 %
              Water (K. F.)≤ 2.0 %
              Ethyl acetate (HS-GC)≤ 0.5 %
              Acetate (IC)≤ 0.1 %
              For TLC-Systems see our General Catalog

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              Product Number PackagingSpecificationLot Number
              8520700001 Glass bottlePDF Specification Document
              8520700005 Glass bottlePDF Specification Document

              Brochure

              Title
              Novabiochem Innovations 01/11
              Novabiochem Letters 02/16
              Novabiochem Phosphopeptide

              Citations

              Title
              • [1] P. White & J. Beythien in 'Innovations & Perspectives in Solid Phase Synthesis and Combinatorial Libraries, 4th International Symposium', Mayflower Scientific Ltd., Birmingham, 1996, pp. 557.
              • [2] T. Vorherr, et al. (1995) Bioorg. Med. Chem. Lett., 5, 2661.
              • [3] H. Schmid, et al., Poster 423 presented at the 15th American Peptide Symposium, Nashville, 1997.

              Reach Use

              Title
              Reach Use