116819 Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 8-Chloro-, Rp-Isomer, Sodium Salt

116819
  
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      Replacement Information

      Tableau de caractéristiques principal

      Empirical FormulaCAS #
      C₁₀H₁₀ClN₅O₅PS · Na 142754-27-6
      Description
      Overview

      This product has been discontinued.





      A cell-permeable, metabolically-stable analog of cAMP that acts as a competitive inhibitor of protein kinase A. Lipophilic analog of the cAMP antagonist Rp-cAMPS (Cat. No. 116814). Preferentially inhibits type I PKA (IC50 = ~50 µM).
      Note: 5 µmol = 2 mg.
      Catalogue Number116819
      Brand Family Calbiochem®
      SynonymsPKA Inhibitor IX, Rp-8-Cl-cAMPS, Na
      References
      ReferencesBraun, C.M., et al. 1998. Biochem Pharmacol. 56, 871.
      Gjertsen, B.T., et al. 1995. J. Biol. Chem. 270, 20599.
      Yokazaki, H., et al. 1992. Cancer Res. 52, 2504.
      Product Information
      CAS number142754-27-6
      ATP CompetitiveY
      DeclarationSold under license of Patent DE 3,802,865.4 issued to BIOLOG LSI.
      FormLyophilized
      Hill FormulaC₁₀H₁₀ClN₅O₅PS · Na
      Chemical formulaC₁₀H₁₀ClN₅O₅PS · Na
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetPKA 1
      Primary Target IC<sub>50</sub>50 µM against PKA 1
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Certificats d'analyse

      TitreNuméro de lot
      116819

      Références bibliographiques

      Aperçu de la référence bibliographique
      Braun, C.M., et al. 1998. Biochem Pharmacol. 56, 871.
      Gjertsen, B.T., et al. 1995. J. Biol. Chem. 270, 20599.
      Yokazaki, H., et al. 1992. Cancer Res. 52, 2504.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-September-2007 RFH
      SynonymsPKA Inhibitor IX, Rp-8-Cl-cAMPS, Na
      DescriptionA cell-permeable, metabolically stable cAMP analog that acts as a competitive inhibitor of PKA (protein kinase A). Preferentially inhibits type I PKA (IC50 ~50 µM). Inhibits cholera toxin- and prostaglandin E1-induced apoptosis in IPC leukemia cells (IC50 ~300 µM). More lipophilic than the parent compound, Rp-cAMPS (Cat. No. 116814). Note: 5 µmol = 2 mg.
      FormLyophilized
      CAS number142754-27-6
      Chemical formulaC₁₀H₁₀ClN₅O₅PS · Na
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (1 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesBraun, C.M., et al. 1998. Biochem Pharmacol. 56, 871.
      Gjertsen, B.T., et al. 1995. J. Biol. Chem. 270, 20599.
      Yokazaki, H., et al. 1992. Cancer Res. 52, 2504.

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      Catégories

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase A (PKA; cAMP-Dependent Protein Kinase) Inhibitors