124019 Akt Inhibitor IX, API-59CJ-OMe - CAS 98510-80-6 - Calbiochem

124019
  
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      Aperçu

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      Tableau de caractéristiques principal

      Empirical FormulaCAS #
      C₂₁H₂₂N₂O₃ • 3H₂O 98510-80-6
      Description
      OverviewA cell-permeable ellipticine compound that potently and selectively induces apoptosis in human endometrial cancer cells (RL95-2 and Ishikawa) that exhibit elevated Akt activity (effective concentration = 12-24 µM), but not on cells with low Akt activity. Directly affects the activity by Akt, but not the level of cellular phosphorylation of Akt, ERK1/2, JNK1/2, PDK1, PKC isoforms, or serum and glucocorticoid-inducible kinase (SGK).
      Catalogue Number124019
      Brand Family Calbiochem®
      SynonymsMMEA, 9-Methoxy-2-methylellipticinium acetate, NSC 627505
      References
      ReferencesJin, X., et al. 2004. Br. J. Cancer 91, 1808.
      Product Information
      CAS number98510-80-6
      ATP CompetitiveN
      FormOrange red solid
      Hill FormulaC₂₁H₂₂N₂O₃ • 3H₂O
      Chemical formulaC₂₁H₂₂N₂O₃ • 3H₂O
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetAkt
      Primary Target IC<sub>50</sub>12-24 µM against Akt
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Certificats d'analyse

      TitreNuméro de lot
      124019

      Références bibliographiques

      Aperçu de la référence bibliographique
      Jin, X., et al. 2004. Br. J. Cancer 91, 1808.

      Brochure

      Titre
      Akt
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-April-2008 RFH
      SynonymsMMEA, 9-Methoxy-2-methylellipticinium acetate, NSC 627505
      DescriptionA cell-permeable ellipticine compound that potently and selectively induces apoptosis in human endometrial cancer cells (RL95-2 and Ishikawa) that exhibit elevated Akt activity (effective concentration = 12-24 µM), but not on cells with low Akt activity. Directly affects the activity by Akt, but not the level of cellular phosphorylation of Akt, ERK1/2, JNK1/2, PDK1, PKC isoforms, or serum and glucocorticoid-inducible kinase (SGK).
      FormOrange red solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number98510-80-6
      Chemical formulaC₂₁H₂₂N₂O₃ • 3H₂O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityH₂O (5 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesJin, X., et al. 2004. Br. J. Cancer 91, 1808.