124017 InSolution™ Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 - Calbiochem

124017
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      Empirical Formula
      C₃₄H₂₉N₇O

      Prix & Disponibilité

      RéférenceDisponibilité Conditionnement Qté Prix Quantité
      124017-1MG
      Récupération des données relatives à la disponibilité...
      Disponibilité limitéeDisponibilité limitée
      En stock 
      Interrompu(e)
      Disponible en quantités limitées
      Disponibilité à confirmer
        Pour le restant : Nous vous tiendrons informé
          Pour le restant : Nous vous tiendrons informé
          Nous vous tiendrons informé
          Contacter le Service Clients
          Contact Customer Service

          Ampoule plast. 1 mg
          Prix en cours de récupération
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          Description
          Catalogue Number124017
          Brand Family Calbiochem®
          References
          ReferencesBarnett, S.F., et al. 2005. Biochem. J. 385, 399.
          DeFeo-Jones, D., et al. 2005. Mol. Cancer Ther. 4, 271.
          Zhao, Z., et al. 2005. Bioorg. Med. Chem. Lett. 15, 905.
          Lindsley, C.W., et al. 2005. Bioorg. Med. Chem. Lett. 15, 761.
          Product Information
          ATP CompetitiveN
          FormLiquid
          FormulationA 10 mM (1 mg/181 µl) solution of Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (Cat. No. 124018) in DMSO.
          Hill FormulaC₃₄H₂₉N₇O
          Chemical formulaC₃₄H₂₉N₇O
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          ApplicationInSolution Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2, CAS 612847-09-3, is a 10 mM solution in DMSO. A cell-permeable, reversible, selective inhibitor of Akt1 & Akt2 (IC50 = 58 nM & 210 nM).
          Biological Information
          Primary TargetAkt1, Akt2, Akt3
          Primary Target IC<sub>50</sub>58 nM, 210 nM, and 2.12 µM for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays
          Purity≥95% by HPLC
          Concentration Label Please refer to vial label for lot-specific concentration
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Irritant
          Storage ≤ -70°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Certificats d'analyse

          TitreNuméro de lot
          124017

          Références bibliographiques

          Aperçu de la référence bibliographique
          Barnett, S.F., et al. 2005. Biochem. J. 385, 399.
          DeFeo-Jones, D., et al. 2005. Mol. Cancer Ther. 4, 271.
          Zhao, Z., et al. 2005. Bioorg. Med. Chem. Lett. 15, 905.
          Lindsley, C.W., et al. 2005. Bioorg. Med. Chem. Lett. 15, 761.

          Brochure

          Titre
          Akt
          Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision24-August-2011 RFH
          DescriptionA cell-permeable, potent, and selective inhibitor of Akt1/Akt2 activity (IC50 = 58 nM, 210 nM, and 2.12 µM for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays). The inhibition is reported to be pleckstrin homology (PH) domain-dependent. It does not exhibit any inhibitory effect against PH domain-lacking Akts, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations as high as 50 µM. Overcomes Akt1/Akt2-mediated resistance to chemotherapeutics in tumor cells and is shown to block basal and stimulated phosphorylation/activation of Akt1/Akt2 both in cultured cells in vitro and in mice in vivo.
          FormLiquid
          FormulationA 10 mM (1 mg/181 µl) solution of Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (Cat. No. 124018) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          Concentration Label Please refer to vial label for lot-specific concentration
          Chemical formulaC₃₄H₂₉N₇O
          Structure formulaStructure formula
          Purity≥95% by HPLC
          Storage ≤ -70°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Toxicity Irritant
          ReferencesBarnett, S.F., et al. 2005. Biochem. J. 385, 399.
          DeFeo-Jones, D., et al. 2005. Mol. Cancer Ther. 4, 271.
          Zhao, Z., et al. 2005. Bioorg. Med. Chem. Lett. 15, 905.
          Lindsley, C.W., et al. 2005. Bioorg. Med. Chem. Lett. 15, 761.