121767 AG 1024 - CAS 65678-07-1 - Calbiochem

121767
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical FormulaCAS #
      C₁₄H₁₃BrN₂O 65678-07-1

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1121767-1MG
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          Description
          OverviewA cell-permeable, reversible, substrate competitive, and specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kinase activity. Exhibits lower IC50 values for IGF-1 than for the insulin receptor. Also inhibits insulin-stimulated cellular proliferation.
          Catalogue Number121767
          Brand Family Calbiochem®
          Synonyms3-Bromo-5-t-butyl-4-hydroxy-benzylidenemalonitrile
          References
          ReferencesWen, B., et al. 2001. Br. J. Cancer 85, 2017.
          Parrizas, M., et al. 1997. Endocrinology 138, 1427.
          Ohmichi, M., et al. 1993. Biochemistry 32, 4650.
          Product Information
          CAS number65678-07-1
          ATP CompetitiveN
          FormOff-white to yellow solid
          Hill FormulaC₁₄H₁₃BrN₂O
          Chemical formulaC₁₄H₁₃BrN₂O
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetIGF-1
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 2 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Certificados de análisis

          CargoNúmero de lote
          121767

          Referencias bibliográficas

          Visión general referencias
          Wen, B., et al. 2001. Br. J. Cancer 85, 2017.
          Parrizas, M., et al. 1997. Endocrinology 138, 1427.
          Ohmichi, M., et al. 1993. Biochemistry 32, 4650.
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-April-2011 RFH
          Synonyms3-Bromo-5-t-butyl-4-hydroxy-benzylidenemalonitrile
          DescriptionA cell-permeable, reversible, substrate competitive, and specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor kinases with significantly lower IC50 values for IGF-1 than for insulin receptors. Induces apoptosis by downregulating the expression of phospho-Akt1 and Bcl-2; and increasing the expression of Bax, p53 and p21. Reported to enhance the radiosensitivity of human breast cancer cells.
          FormOff-white to yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number65678-07-1
          Chemical formulaC₁₄H₁₃BrN₂O
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 2 months at -20°C.
          Toxicity Standard Handling
          ReferencesWen, B., et al. 2001. Br. J. Cancer 85, 2017.
          Parrizas, M., et al. 1997. Endocrinology 138, 1427.
          Ohmichi, M., et al. 1993. Biochemistry 32, 4650.