121765 AG 825 - CAS 149092-50-2 - Calbiochem

121765
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical FormulaCAS #
      C₁₉H₁₅N₃O₃S₂ 149092-50-2

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1121765-2MG
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          Ampolla de plást. 2 mg
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          Description
          OverviewA potent, cell-premeable, reversible, substrate competitive, and selective inhibitor of HER2 (neu/ErbB2; IC50 = 0.35 µM) relative to HER1 (IC50 = 19 µM) autophosphorylation. The inhibition is competitive with respect to ATP binding. Enhances chemosensitivity in non-small cell lung cancer (NSCLC) cell lines expressing high levels of p185neu.
          Catalogue Number121765
          Brand Family Calbiochem®
          Synonyms4-Hydroxy-3-methoxy-5-(benzothiazolylthiomethyl)benzylidenecyanoacetamide
          References
          ReferencesAshton, J.M., et al. 2012. Cell Stem Cell 11, 359.
          Tsai, C.M., et al. 1996. Cancer Res. 56, 1068.
          Levitzki, A., and Gazit, A. 1995. Science 267, 1782.
          Osherov, N., et al. 1993. J. Biol. Chem. 268, 11134.
          Product Information
          CAS number149092-50-2
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₁₉H₁₅N₃O₃S₂
          Chemical formulaC₁₉H₁₅N₃O₃S₂
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetHER2
          Primary Target IC<sub>50</sub>0.35 µM against HER2
          Purity≥94% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2-3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Licencias necesarias

          Título
          CARTA DE USO GENERAL 2016
          PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

          Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Certificados de análisis

          CargoNúmero de lote
          121765

          Referencias bibliográficas

          Visión general referencias
          Ashton, J.M., et al. 2012. Cell Stem Cell 11, 359.
          Tsai, C.M., et al. 1996. Cancer Res. 56, 1068.
          Levitzki, A., and Gazit, A. 1995. Science 267, 1782.
          Osherov, N., et al. 1993. J. Biol. Chem. 268, 11134.
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision24-March-2015 JSW
          Synonyms4-Hydroxy-3-methoxy-5-(benzothiazolylthiomethyl)benzylidenecyanoacetamide
          DescriptionA potent, cell-premeable, reversible, substrate competitive, and selective inhibitor of HER-2 (neu/erbB-2, IC50 = 0.35 µM) relative to HER-1 (IC50 = 19 µM) autophosphorylation. The inhibition is competitive with respect to ATP binding. Enhances the chemosensitivity in non-small cell lung cancer (NSCLC) cell lines expressing high levels of p185neu.
          FormYellow solid
          CAS number149092-50-2
          Chemical formulaC₁₉H₁₅N₃O₃S₂
          Structure formulaStructure formula
          Purity≥94% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2-3 months at -20°C.
          Toxicity Standard Handling
          ReferencesAshton, J.M., et al. 2012. Cell Stem Cell 11, 359.
          Tsai, C.M., et al. 1996. Cancer Res. 56, 1068.
          Levitzki, A., and Gazit, A. 1995. Science 267, 1782.
          Osherov, N., et al. 1993. J. Biol. Chem. 268, 11134.