123040 AICA-Riboside - CAS 2627-69-2 - Calbiochem

123040
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical FormulaCAS #
      C₉H₁₄N₄O₅ 2627-69-2

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1123040-50MG
      Comprobando disponibilidad...
      Disponibilidad a confirmarDisponibilidad a confirmar
      En existencia 
      Suspendido
      Cantidades limitadas disponibles
      Debe confirmarse disponibilidad
        El resto: se avisará
          El resto: se avisará
          Se avisará
          Póngase en contacto con el Servicio de Atención al Cliente
          Contact Customer Service

          Ampolla de plást. 50 mg
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          Description
          OverviewA cell-permeable nucleoside compound whose phosphorylated metabolite activates adenosine monophosphate-activated protein kinase (AMPK) and acts as a regulator of de novo purine synthesis. Stimulates glucose uptake in perfused and isolated muscle. Offers protection against cell death induced by glucose deprivation, chemical hypoxia, and exposure to glutamate and Aβ peptide.
          Catalogue Number123040
          Brand Family Calbiochem®
          SynonymsAcadesine, AICAr, 5-Aminoimidazole-4-carboxamide-1-β-riboside, Z-Riboside, AMPK Signaling Activator II
          References
          ReferencesMeli, M., et al. 2006. J. Med. Chem. in press.
          Culmsee, C., et al. 2001. J. Mol. Neurosci. 17, 45.
          Muoio, D.M., et al. 1999. Biochem. J. 338, 783.
          Hayashi, T., et al. 1998. Diabetes 47, 1369.
          Corton, J.M., et al. 1995. Eur. J. Biochem. 229, 558.
          Product Information
          CAS number2627-69-2
          ATP CompetitiveN
          FormTan solid
          Hill FormulaC₉H₁₄N₄O₅
          Chemical formulaC₉H₁₄N₄O₅
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetAdenosine monophosphate-activated protein kinase (AMPK)
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Licencias necesarias

          Título
          CARTA DE USO GENERAL 2016
          PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

          Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Certificados de análisis

          CargoNúmero de lote
          123040

          Referencias bibliográficas

          Visión general referencias
          Meli, M., et al. 2006. J. Med. Chem. in press.
          Culmsee, C., et al. 2001. J. Mol. Neurosci. 17, 45.
          Muoio, D.M., et al. 1999. Biochem. J. 338, 783.
          Hayashi, T., et al. 1998. Diabetes 47, 1369.
          Corton, J.M., et al. 1995. Eur. J. Biochem. 229, 558.
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-April-2008 RFH
          SynonymsAcadesine, AICAr, 5-Aminoimidazole-4-carboxamide-1-β-riboside, Z-Riboside, AMPK Signaling Activator II
          DescriptionA cell-permeable nucleoside compound that is processed intracellularly to form a phosphorylated metabolite, which activates adenosine monophosphate-activated protein kinase (AMPK) without disrupting the cellular concentrations of ATP, ADP, or AMP. Also acts as a regulator of de novo purine synthesis. Stimulates glucose uptake in both perfused and isolated muscle. AICAr-stimulated glucose transport is not affected by Wortmannin (Cat. No. 681675), a PI-3K inhibitor. Shown to inhibit the synthesis of triacylglycerol (TAG), diacylglycerol (DAG), and phospholipid, probably as a result of AMPK activation and the subsequent inhibition of sn-glycerol-3-phosphate acyltransferase (GPAT) by AMPK. Also reported to inhibit Hsp90 chaperone function. Imparts protection against cell death induced by glucose deprivation, chemical hypoxia, and exposure to glutamate and amyloid β (Aβ) peptide.
          FormTan solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number2627-69-2
          Chemical formulaC₉H₁₄N₄O₅
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityMethanol (10 mg/ml) or H₂O. May require heating to 50°C to achieve complete solubilization in methanol.
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesMeli, M., et al. 2006. J. Med. Chem. in press.
          Culmsee, C., et al. 2001. J. Mol. Neurosci. 17, 45.
          Muoio, D.M., et al. 1999. Biochem. J. 338, 783.
          Hayashi, T., et al. 1998. Diabetes 47, 1369.
          Corton, J.M., et al. 1995. Eur. J. Biochem. 229, 558.