182200 βARK1 Inhibitor - CAS 24269-96-3 - Calbiochem

182200
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical FormulaCAS #
      C₁₂H₉NO₆ 24269-96-3

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1182200-5MG
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          Ampolla de plást. 5 mg
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          Description
          OverviewA selective inhibitor of βARK1 (β-Adrenergic Receptor Kinase 1) (IC50 = 126 µM). Has no inhibitory activity against protein kinase A (PKA).
          Catalogue Number182200
          Brand Family Calbiochem®
          Synonymsβ-Adrenergic Receptor Kinase1 Inhibitor, GRK2 Inhibitor, Methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate
          References
          ReferencesIino, M., et al. 2002. J. Med. Chem. 45, 2150.
          Product Information
          CAS number24269-96-3
          ATP CompetitiveN
          FormYellow to orange solid
          Hill FormulaC₁₂H₉NO₆
          Chemical formulaC₁₂H₉NO₆
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetβARK1 (β-Adrenergic Receptor Kinase 1)
          Primary Target IC<sub>50</sub>126 µM against βARK1 (β-Adrenergic Receptor Kinase 1)
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Certificados de análisis

          CargoNúmero de lote
          182200

          Referencias bibliográficas

          Visión general referencias
          Iino, M., et al. 2002. J. Med. Chem. 45, 2150.
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision30-August-2016 JSW
          Synonymsβ-Adrenergic Receptor Kinase1 Inhibitor, GRK2 Inhibitor, Methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate
          DescriptionA selective inhibitor of β-adrenergic receptor kinase 1 (βARK1) (IC50 = 126 µM). Displays no inhibitory activity against protein kinase A (PKA). Identified from a group of existing compounds (not previously demonstrated to inhibit βARK1) using a two-step rational drug design protocol that included molecular modeling and comparative docking studies. Represents the first inhibitor that distinguishes between βARK1 and PKA, an enzyme with a similar adenine binding pocket. May be useful in the study of mechanisms involved in congestive heart failure where elevated levels of βARK1 desensitize agonist-bound β2-adrenergic receptors.
          FormYellow to orange solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number24269-96-3
          Chemical formulaC₁₂H₉NO₆
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (5 mg/ml) or Methanol
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesIino, M., et al. 2002. J. Med. Chem. 45, 2150.