114802 | AdaAhx₃L₃VS - CAS 389064-25-9 - Calbiochem

114802
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical FormulaCAS #
      C₅₀H₈₈N₆O₈S 389064-25-9

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1114802-250UG
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      Disponibilidad a confirmarDisponibilidad a confirmar
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          Ampolla de plást. 250 μg
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          Description
          OverviewA potent, covalent, cell-permeable, irreversible inhibitor of chymotrypsin-like (50-100 nM), trypsin-like (1-5 µM), and PGPH (0.5-1 µM) activities of the 20S proteasome.
          Catalogue Number114802
          Brand Family Calbiochem®
          SynonymsAdamantane-acetyl-(6-aminohexanoyl)₃-(leucinyl)₃-vinyl-(methyl)-sulfone, Proteasome Inhibitor XVI
          References
          ReferencesKessler, B.M., et al. 2001. Chem. Biol. 8, 913.
          Product Information
          CAS number389064-25-9
          ATP CompetitiveN
          FormOff-white powder
          Hill FormulaC₅₀H₈₈N₆O₈S
          Chemical formulaC₅₀H₈₈N₆O₈S
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetchymotrypsin-like activity of the 20S proteasome
          Primary Target IC<sub>50</sub>50-100 nM against chymotrypsin-like activity of the 20S proteasome
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Certificados de análisis

          CargoNúmero de lote
          114802

          Referencias bibliográficas

          Visión general referencias
          Kessler, B.M., et al. 2001. Chem. Biol. 8, 913.

          Folleto

          Cargo
          Caspases and other Apoptosis Related Tools Brochure
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-October-2007 RFH
          SynonymsAdamantane-acetyl-(6-aminohexanoyl)₃-(leucinyl)₃-vinyl-(methyl)-sulfone, Proteasome Inhibitor XVI
          DescriptionA cell-permeable, peptide vinyl sulfone that acts as a potent, irreversible inhibitor of proteasome activity. Covalently modifies the catalytically active β-subunits of the proteasome. Shown to inhibit the chymotrypsin-like (10-50 nM), trypsin-like (1-5 µM), and the peptidyl glutamyl peptide hydrolyzing (PGPH) (0.5-1 µM) activities of purified 20S proteasomes from rabbit muscle. Inhibits proteasomal degradation of deglycosylated MHC HLA-A2 heavy chain in US11+ cells (~50 µM).
          FormOff-white powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number389064-25-9
          Chemical formulaC₅₀H₈₈N₆O₈S
          Structure formulaStructure formula
          Purity≥90% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesKessler, B.M., et al. 2001. Chem. Biol. 8, 913.