116816 Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 8-Bromo-, Rp-Isomer, Sodium Salt - Calbiochem

116816
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical Formula
      C₁₀H₁₀BrN₅O₅PS · Na

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1116816-5UMOL
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          Ampolla de plást. 5 umol
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          Description
          OverviewA potent, cell-permeable, and reversible metabolically-stable cAMP antagonist that inhibits cAMP-dependent protein kinase and shows preference for PKA type I. More lipophilic than cAMP antagonist Rp-cAMPS (Cat. No. 116814).
          Note: 5 µmol = 2.23 mg.
          Catalogue Number116816
          Brand Family Calbiochem®
          SynonymsRp-8-Br-cAMPS, Na, PKA Inhibitor VI
          References
          ReferencesCalaghan, S.C., et al. 1999. Pflugers Arch. 437, 780.
          Gjertsen, B.T., et al. 1995. J. Biol. Chem. 270, 20599.
          Yokozaki, H., et al. 1992. Cancer Res. 52, 2504.
          Dostmann, W.R. et al. 1990. J. Biol. Chem. 265, 10484.
          Product Information
          ATP CompetitiveN
          DeclarationSold under license of Patent DE 3,802,865.4 issued to BIOLOG LSI.
          FormLyophilized
          Hill FormulaC₁₀H₁₀BrN₅O₅PS · Na
          Chemical formulaC₁₀H₁₀BrN₅O₅PS · Na
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetPKA 1
          Purity≥99% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Licencias necesarias

          Título
          CARTA DE USO GENERAL 2016
          PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

          Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Certificados de análisis

          CargoNúmero de lote
          116816

          Referencias bibliográficas

          Visión general referencias
          Calaghan, S.C., et al. 1999. Pflugers Arch. 437, 780.
          Gjertsen, B.T., et al. 1995. J. Biol. Chem. 270, 20599.
          Yokozaki, H., et al. 1992. Cancer Res. 52, 2504.
          Dostmann, W.R. et al. 1990. J. Biol. Chem. 265, 10484.

          Folleto

          Cargo
          Inhibitor Sourcebook 3rd Edition - Merck

          Citas

          Título
        • Ralf Gutzmer, et al. (2005) Histamine H4 receptor stimulation suppresses IL-12p70 production and mediates chemotaxis in human monocyte-derived dendritic cells. Journal of Immunology 5224-5232.
        • Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-January-2010 RFH
          SynonymsRp-8-Br-cAMPS, Na, PKA Inhibitor VI
          DescriptionCell-permeable, potent, reversible, and metabolically stable antagonist of cAMP that is resistant to the action of mammalian cyclic nucleotide phosphodiesterases. Rp-8-Br-cAMPS is more lipophilic as compared to 8-Br-cAMP and Rp-cAMPS. In contrast to other common ATP-site inhibitors or to its parent compound Rp-cAMPS, Rp-8-Br-cAMPS discriminates between both isozymes of protein kinase A, preferring type I, thus providing additional selectivity. By occupying cAMP binding sites, prevents dissociation and activation of the kinase holoenzyme. λ = 264 nm (H2O, pH 7.0); εmax 17,000 M-1cm-1.
          FormLyophilized
          Chemical formulaC₁₀H₁₀BrN₅O₅PS · Na
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityH₂O (40 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesCalaghan, S.C., et al. 1999. Pflugers Arch. 437, 780.
          Gjertsen, B.T., et al. 1995. J. Biol. Chem. 270, 20599.
          Yokozaki, H., et al. 1992. Cancer Res. 52, 2504.
          Dostmann, W.R. et al. 1990. J. Biol. Chem. 265, 10484.
          Citation
        • Ralf Gutzmer, et al. (2005) Histamine H4 receptor stimulation suppresses IL-12p70 production and mediates chemotaxis in human monocyte-derived dendritic cells. Journal of Immunology 5224-5232.