116818 | Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 8-Bromo-, Sp-Isomer, Sodium Salt - Calbiochem

116818
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical Formula
      C₁₀H₁₀BrN₅O₅PS · Na

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1116818-5UMOL
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          Ampolla de plást. 5 umol
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          Description
          OverviewA potent cell-permeable, metabolically-stable activator of cAMP-dependent protein kinase (PKA). Induces guanine nucleotide exchange factor activity of GEFI (also known as Epac) and GEFII towards Rap1 both in vivo and in vitro. Significantly more lipophilic and cell-permeable than Sp-cAMPS (Cat. No. 116815). Note: 5 µmol = 2.23 mg.
          Catalogue Number116818
          Brand Family Calbiochem®
          SynonymsSp-8-Br-cAMPS, Na
          References
          ReferencesKawasaki, H., et al. 1998. Science 282, 2275.
          de Rooij, J., et al. 1998. Nature 396, 474.
          Holen, I., et al. 1996. Eur. J. Biochem. 236, 163.
          Schaap, P., et al. 1993. J. Biol. Chem. 268, 6323.
          Yokozaki, H., et al. 1992. Cancer Res. 52, 2504.
          Product Information
          ATP CompetitiveN
          DeclarationSold under license of Patent DE 3,802,865.4 issued to BIOLOG LSI.
          FormLyophilized
          Hill FormulaC₁₀H₁₀BrN₅O₅PS · Na
          Chemical formulaC₁₀H₁₀BrN₅O₅PS · Na
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetPKA
          Purity≥99% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Certificados de análisis

          CargoNúmero de lote
          116818

          Referencias bibliográficas

          Visión general referencias
          Kawasaki, H., et al. 1998. Science 282, 2275.
          de Rooij, J., et al. 1998. Nature 396, 474.
          Holen, I., et al. 1996. Eur. J. Biochem. 236, 163.
          Schaap, P., et al. 1993. J. Biol. Chem. 268, 6323.
          Yokozaki, H., et al. 1992. Cancer Res. 52, 2504.

          Folleto

          Cargo
          Nucleotides and Bases Technical Bulletin
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-September-2007 RFH
          SynonymsSp-8-Br-cAMPS, Na
          DescriptionA potent cell-permeable, metabolically stable activator of cAMP-dependent protein kinase (PKA). Induces the guanine-nucleotide-exchange factor activity of GEFI, also known as Epac (exchange protein directly activated by cAMP), and GEFII towards Rap1 both in vivo and in vitro. Significantly more lipophilic and cell permeable than Sp-cAMPS (Cat. No. 116815). λmax = 264 nm (H2O, pH 7.0); εmax = 17,000 M-1cm-1. Note: 5 µmol = 2.23 mg.
          FormLyophilized
          Chemical formulaC₁₀H₁₀BrN₅O₅PS · Na
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityH₂O (40 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesKawasaki, H., et al. 1998. Science 282, 2275.
          de Rooij, J., et al. 1998. Nature 396, 474.
          Holen, I., et al. 1996. Eur. J. Biochem. 236, 163.
          Schaap, P., et al. 1993. J. Biol. Chem. 268, 6323.
          Yokozaki, H., et al. 1992. Cancer Res. 52, 2504.