124009 Akt Inhibitor III - Calbiochem

124009
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical Formula
      C₂₈H₅₇O₉P

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1124009-1MG
      Comprobando disponibilidad...
      Disponibilidad a confirmarDisponibilidad a confirmar
      En existencia 
      Suspendido
      Cantidades limitadas disponibles
      Debe confirmarse disponibilidad
        El resto: se avisará
          El resto: se avisará
          Se avisará
          Póngase en contacto con el Servicio de Atención al Cliente
          Contact Customer Service

          Ampolla de plást. 1 mg
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          Description
          OverviewA cell permeable, reversible, and substrate competitive phosphatidylinositol analog that inhibits the activation of Akt and select downstream substrates without decreasing phosphorylation of PDK-1 or other kinases downstream of Ras, such as MAPK. Also acts as a potent inducer of apoptosis and selectively kills a variety of cancer cell lines that contain high levels of active Akt. When used at a concentration of 10 µM, it is reported to activate p38α/SAPK2α MAP kinase. At 10 µM it will also inhibit PKA activity.
          Catalogue Number124009
          Brand Family Calbiochem®
          SynonymsSH-6
          References
          ReferencesGills, J.J., et al. 2007. J. Biol. Chem. in press.
          Kozikowski, A.P., et al. 2003. J. Am. Chem. Soc.125, 1144.
          Product Information
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₈H₅₇O₉P
          Chemical formulaC₂₈H₅₇O₉P
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetAkt
          Purity≥98% by NMR
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Certificados de análisis

          CargoNúmero de lote
          124009

          Referencias bibliográficas

          Visión general referencias
          Gills, J.J., et al. 2007. J. Biol. Chem. in press.
          Kozikowski, A.P., et al. 2003. J. Am. Chem. Soc.125, 1144.

          Folleto

          Cargo
          Akt
          Biologics 31.1
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-October-2007 RFH
          SynonymsSH-6
          DescriptionA phosphatidylinositol analog that inhibits the activation of Akt and selected downstream substrates without affecting the phosphorylation of PDK-1 and other downstream kinases. Decreases phosphorylation of Akt without affecting the total Akt level. Reported to be a potent inducer of apoptosis and to selectively kill a variety of cancer cell lines expressing high levels of active Akt. When used at a concentration of 10 µM, it is reported to activate p38α/SAPK2α MAP kinase. At 10 µM it will also inhibit PKA activity.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₈H₅₇O₉P
          Structure formulaStructure formula
          Purity≥98% by NMR
          SolubilityDMSO (10 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesGills, J.J., et al. 2007. J. Biol. Chem. in press.
          Kozikowski, A.P., et al. 2003. J. Am. Chem. Soc.125, 1144.