124013 Akt Inhibitor VI, Akt-in - Calbiochem

124013
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical Formula
      C₈₈H₁₂₃N₂₃O₂₃

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1124013-2MG
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      Disponibilidad a confirmarDisponibilidad a confirmar
      En existencia 
      Suspendido
      Cantidades limitadas disponibles
      Debe confirmarse disponibilidad
        El resto: se avisará
          El resto: se avisará
          Se avisará
          Póngase en contacto con el Servicio de Atención al Cliente
          Contact Customer Service

          Ampolla de plást. 2 mg
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          Description
          OverviewA reversible 15-mer peptide derived from proto-oncogene TCL1 (amino acids 10-24) that acts as a specific inhibitor of Akt. Shown to bind to Akt-PH domain (Kd ~18 µM) and interfere with the Akt-phosphoinositide interaction, thus hindering membrane translocation from the cytosol and downstream biological responses.
          Catalogue Number124013
          Brand Family Calbiochem®
          SynonymsTCL1₁₀₋₂₄, H-AVTDHPDRLWAWEKF-OH
          References
          ReferencesHiromura, M., et al. 2004. J. Biol. Chem. 279, 53407.
          Product Information
          ATP CompetitiveN
          FormWhite lyophilized solid
          FormulationSupplied as an acetate salt.
          Hill FormulaC₈₈H₁₂₃N₂₃O₂₃
          Chemical formulaC₈₈H₁₂₃N₂₃O₂₃
          Hygroscopic Hygroscopic
          ReversibleY
          Applications
          Biological Information
          Primary TargetAkt
          Primary Target IC<sub>50</sub>Kd ~18 µM in binding to Akt-PH domain
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceH-Ala-Val-Thr-Asp-His-Pro-Asp-Arg-Leu-Trp-Ala-Trp-Glu-Lys-Phe-OH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Certificados de análisis

          CargoNúmero de lote
          124013

          Referencias bibliográficas

          Visión general referencias
          Hiromura, M., et al. 2004. J. Biol. Chem. 279, 53407.

          Folleto

          Cargo
          Akt
          Biologics 31.1
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision23-November-2009 RFH
          SynonymsTCL1₁₀₋₂₄, H-AVTDHPDRLWAWEKF-OH
          DescriptionA reversible 15-mer peptide derived from the amino acids 10-24 of the proto-oncogene TCL1 (TCL10-24) and acts as a specific inhibitor of Akt. Shown to bind to the Akt-PH domain (Kd ~18 µM) and interfere with the Akt-phosphoinositide interaction. This peptide, when made cell-permeable (Cat. No. 124014), has been shown to hinder Akt membrane translocation from the cytosol and subsequent downstream biological responses.
          FormWhite lyophilized solid
          FormulationSupplied as an acetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₈₈H₁₂₃N₂₃O₂₃
          Peptide SequenceH-Ala-Val-Thr-Asp-His-Pro-Asp-Arg-Leu-Trp-Ala-Trp-Glu-Lys-Phe-OH
          Purity≥95% by HPLC
          SolubilityH₂O (1 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          ReferencesHiromura, M., et al. 2004. J. Biol. Chem. 279, 53407.