126870 Alsterpaullone - CAS 237430-03-4 - Calbiochem

126870
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical FormulaCAS #
      C₁₆H₁₁N₃O₃ 237430-03-4

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1126870-1MG
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          Ampolla de plást. 1 mg
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          Description
          OverviewA cell-permeable, potent, reversible, and ATP competitive inhibitor of GSK-3β (IC50 = 4 nM) and Cdk1/cyclin B (IC50 = 35 nM). Displays remarkable in vitro antitumor activity. Inhibits Tau phosphorylation at sites that are typically phosphorylated by GSK-3β in Alzheimer’s disease. Also inhibits Cdk5/p25-dependent phosphorylation of DARPP-32.
          Catalogue Number126870
          Brand Family Calbiochem®
          Synonyms9-Nitro-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one, 9-Nitropaullone, NSC 705701
          References
          ReferencesLeost, M., et al. 2000. Eur. J. Biochem. 267, 5983.
          Schultz, C., et al. 1999. J. Med. Chem. 42, 2909.
          Product Information
          CAS number237430-03-4
          ATP CompetitiveY
          FormBrown solid
          Hill FormulaC₁₆H₁₁N₃O₃
          Chemical formulaC₁₆H₁₁N₃O₃
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetGSK-3β, Cdk1/cyclin B
          Primary Target IC<sub>50</sub>4 nM, 35 nM, against GSK-3β, Cdk1/cyclin B, respectively
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Certificados de análisis

          CargoNúmero de lote
          126870

          Referencias bibliográficas

          Visión general referencias
          Leost, M., et al. 2000. Eur. J. Biochem. 267, 5983.
          Schultz, C., et al. 1999. J. Med. Chem. 42, 2909.

          Folleto

          Cargo
          Alzheimer's Disease Brochure & Technical Guide
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision16-December-2009 RFH
          Synonyms9-Nitro-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one, 9-Nitropaullone, NSC 705701
          DescriptionA cell-permeable, potent, reversible, and ATP competitive inhibitor of cdk1/cyclin B (IC50 = 35 nM) and GSK-3β (IC50 = 4 nM). One of the most active paullones that acts by competing with ATP for binding to GSK-3β and inhibits the phosphorylation of tau. Also inhibits the activity of Cdk5/p25-dependent phosphorylation of DARPP-32 (a 32 kDa dopamine and adenosine 3',5'-monophosphate-regulated phosphoprotein). Displays remarkable antitumor activity in vitro. Inhibits growth of the colon cancer cell line HCT-116, with an IC50 in the nanomolar range.
          FormBrown solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number237430-03-4
          Chemical formulaC₁₆H₁₁N₃O₃
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (20 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesLeost, M., et al. 2000. Eur. J. Biochem. 267, 5983.
          Schultz, C., et al. 1999. J. Med. Chem. 42, 2909.