164640 Aminopurvalanol A - CAS 220792-57-4 - Calbiochem

164640
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical FormulaCAS #
      C₁₉H₂₆ClN₇O 220792-57-4

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1164640-5MG
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          Ampolla de plást. 5 mg
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          Description
          OverviewA cell-permeable 2,6,9-trisubstituted purine analog that displays anti-mitotic as well as anti-tumor properties (GI50 = ~ 1.8 µM in the NCI 60-cell panel in vitro activity screen; potently inhibits the growth of KM12 colon cancer cells with a GI50 of 30 nM). Acts as a reversible and ATP-competitive inhibitor of Cdks (IC50 = 33 nM for Cdk1/cyclin B and Cdk2/cyclin A, 28 nM for Cdk2/cyclin E, and 20 nM for Cdk5/p35), and displays ~ 100-fold greater selectivity over a panel of kinases tested (IC50 ≥ 2.4 µM). Shown to induce cell differentiation by preferentially targeting the G2/M-phase and act intracellularly by inhibiting both Cdks and MAPKs.
          Catalogue Number164640
          Brand Family Calbiochem®
          Synonyms(2R)-2-((6-((3-Amino-5-chlorophenyl)amino)-9-(1-methylethyl)-9H-purin-2-yl)amino)-3-methyl-1-butanol, NG-97
          References
          ReferencesBreton, M.L., et al. 2003. Biochem. Biophys. Res. Commun. 306, 880.
          Knockaert, M., et al. 2002.Oncogene 21, 6413.
          Adachi, S., et al. 2001. Mol. Cell. Biol. 21, 4929.
          Knockaert, M., et al. 2000. Chem. Biol. 7, 411.
          Rosiana, G.R., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 4797.
          Chang, Y.T., et al. 1999. Chem. Biol. 6, 361.
          Product Information
          CAS number220792-57-4
          ATP CompetitiveY
          DeclarationSold under license of U.S. Patent 6,255,485 and 6,617,331.
          FormPale yellow solid
          Hill FormulaC₁₉H₂₆ClN₇O
          Chemical formulaC₁₉H₂₆ClN₇O
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p35
          Primary Target IC<sub>50</sub>33 nM for Cdk1/cyclin B and Cdk2/cyclin A, 28 nM for Cdk2/cyclin E, and 20 nM for Cdk5/p35
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Licencias necesarias

          Título
          CARTA DE USO GENERAL 2016
          PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

          Aminopurvalanol A - CAS 220792-57-4 - Calbiochem Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Aminopurvalanol A - CAS 220792-57-4 - Calbiochem Certificados de análisis

          CargoNúmero de lote
          164640

          Referencias bibliográficas

          Visión general referencias
          Breton, M.L., et al. 2003. Biochem. Biophys. Res. Commun. 306, 880.
          Knockaert, M., et al. 2002.Oncogene 21, 6413.
          Adachi, S., et al. 2001. Mol. Cell. Biol. 21, 4929.
          Knockaert, M., et al. 2000. Chem. Biol. 7, 411.
          Rosiana, G.R., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 4797.
          Chang, Y.T., et al. 1999. Chem. Biol. 6, 361.
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision10-April-2008 RFH
          Synonyms(2R)-2-((6-((3-Amino-5-chlorophenyl)amino)-9-(1-methylethyl)-9H-purin-2-yl)amino)-3-methyl-1-butanol, NG-97
          DescriptionA cell-permeable 2,6,9-trisubstituted purine analog that displays anti-mitotic as well as anti-tumor properties (GI50 ~1.8 µM in the NCI 60-cell panel in vitro activity screen; potently inhibits the growth of KM12 colon cancer cells with a GI50 of 30 nM). Acts as a reversible and ATP-competitive inhibitor of Cdks (IC50 = 33 nM for Cdk1/cyclin B and Cdk2/cyclin A, 28 nM for Cdk2/cyclin E, and 20 nM for Cdk5/p35), and displays ~100-fold greater selectivity over a panel of kinases tested (IC50 ≥2.4 µM). Shown to induce cell differentiation by preferentially targeting the G2/M-phase and act intracellularly by inhibiting both Cdks and MAPKs.
          FormPale yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number220792-57-4
          Chemical formulaC₁₉H₂₆ClN₇O
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (40 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Irritant
          ReferencesBreton, M.L., et al. 2003. Biochem. Biophys. Res. Commun. 306, 880.
          Knockaert, M., et al. 2002.Oncogene 21, 6413.
          Adachi, S., et al. 2001. Mol. Cell. Biol. 21, 4929.
          Knockaert, M., et al. 2000. Chem. Biol. 7, 411.
          Rosiana, G.R., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 4797.
          Chang, Y.T., et al. 1999. Chem. Biol. 6, 361.