175580 Angiogenesis Inhibitor - CAS 186611-44-9 - Calbiochem

175580
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical FormulaCAS #
      C₁₂H₉N₃O 186611-44-9

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1175580-10MG
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          Ampolla de plást. 10 mg
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          Description
          OverviewA cell-permeable indolinone compound that displays anti-angiogenesis properties (30% inhibition of control at 10 µM in an in vitro rat aortic ring model ) with a potency that is comparable to that of SU5416 (Cat. No. 676487; 22% inhibition of control at 10 µM). Acts as a moderate ATP-competitive inhibitor of hEGF-R tyrosine kinase activity (54% inhibition at 10 µM).
          Catalogue Number175580
          Brand Family Calbiochem®
          Synonyms(Z,E)-3-(Imidazol-4-ylmethylene)indolin-2-one
          References
          ReferencesBraud, E., et al. 2003. J. Enzyme Inhib. Med. Chem. 18, 243.
          Product Information
          CAS number186611-44-9
          ATP CompetitiveY
          FormYellow solid
          Hill FormulaC₁₂H₉N₃O
          Chemical formulaC₁₂H₉N₃O
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargethEGF-R tyrosine kinase activity
          Primary Target IC<sub>50</sub>54% inhibition at 10 µM against hEGF-R tyrosine kinase activity
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Angiogenesis Inhibitor - CAS 186611-44-9 - Calbiochem Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Angiogenesis Inhibitor - CAS 186611-44-9 - Calbiochem Certificados de análisis

          CargoNúmero de lote
          175580

          Referencias bibliográficas

          Visión general referencias
          Braud, E., et al. 2003. J. Enzyme Inhib. Med. Chem. 18, 243.
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-April-2011 RFH
          Synonyms(Z,E)-3-(Imidazol-4-ylmethylene)indolin-2-one
          DescriptionA cell-permeable indolinone compound that displays anti-angiogenesis properties (30% inhibition of control at 10 µM in an in vitro rat aortic ring model). The potency has been reported to be comparable to that of SU5416 (Cat. No. 676487; 22% inhibition of control at 10 µM). Acts as a moderate ATP-competitive inhibitor of hEGF-R tyrosine kinase activity (54% inhibition at 10 µM).
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number186611-44-9
          Chemical formulaC₁₂H₉N₃O
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          ReferencesBraud, E., et al. 2003. J. Enzyme Inhib. Med. Chem. 18, 243.