176901 Anthrax Lethal Factor Protease Inhibitor, In-2-LF - Calbiochem

176901
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical Formula
      C₈₁H₁₅₀N₄₂O₁₇

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1176901-1MG
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      Debe confirmarse disponibilidad
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          Ampolla de plást. 1 mg
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          Description
          OverviewA cell-permeable N-acetylated, C-hydroxamate derivative of a 14-mer peptide designed from the MEK-2 template that acts as a competitive inhibitor of Anthrax lethal factor (LF) metalloprotease (Ki = 1 nM). Also inhibits MEK-3 cleavage. Protects against Anthrax toxin induced cytotoxicity in RAW264.7 and J772.A1 cells.
          Catalogue Number176901
          Brand Family Calbiochem®
          SynonymsAnthrax LF Protease Inhibitor, Bacillus anthracis LF Protease Inhibitor, In-2-LF
          References
          ReferencesPeinado, J.R., et al. 2004. Biochem. Biophys. Res. Commun. 321, 601.
          Tonello, F., et. al. 2002. Nature 418, 386.
          Product Information
          ATP CompetitiveN
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₈₁H₁₅₀N₄₂O₁₇
          Chemical formulaC₈₁H₁₅₀N₄₂O₁₇
          Hygroscopic Hygroscopic
          ReversibleN
          Applications
          Biological Information
          Primary Targetanthrax LF metalloprotease
          Primary Target K<sub>i</sub>1 nM against Anthrax lethal factor (LF) metalloprotease
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceAc-Gly-Tyr-βAla-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Val-Leu-Arg-NHOH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Licencias necesarias

          Título
          CARTA DE USO GENERAL 2016
          PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

          Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Certificados de análisis

          CargoNúmero de lote
          176901

          Referencias bibliográficas

          Visión general referencias
          Peinado, J.R., et al. 2004. Biochem. Biophys. Res. Commun. 321, 601.
          Tonello, F., et. al. 2002. Nature 418, 386.
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision14-April-2008 RFH
          SynonymsAnthrax LF Protease Inhibitor, Bacillus anthracis LF Protease Inhibitor, In-2-LF
          DescriptionA cell-permeable derivative of a 14-mer peptide that is based on the MEK-2 template and acts as a competitive inhibitor of Anthrax lethal factor metalloprotease (Ki = 1 nM). Also inhibits MEK-3 cleavage. Exhibits protective effects against Anthrax toxin-induced cytotoxicity in RAW264.7 and J772.A1 cells. Reported to competitively inhibit furin (Ki = 49 nM.
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₈₁H₁₅₀N₄₂O₁₇
          Peptide SequenceAc-Gly-Tyr-βAla-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Val-Leu-Arg-NHOH
          Purity≥97% by HPLC
          SolubilityDMSO (5 mg/ml), 5% Acetic Acid (5 mg/ml), or H₂O (1 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesPeinado, J.R., et al. 2004. Biochem. Biophys. Res. Commun. 321, 601.
          Tonello, F., et. al. 2002. Nature 418, 386.