178270 Apamin, Bee Venom - CAS 24345-16-2 - Calbiochem

178270
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical FormulaCAS #
      C₇₉H₁₃₁N₃₁O₂₄S₄ 24345-16-2

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1178270-500UG
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      Disponibilidad a confirmarDisponibilidad a confirmar
      En existencia 
      Suspendido
      Cantidades limitadas disponibles
      Debe confirmarse disponibilidad
        El resto: se avisará
          El resto: se avisará
          Se avisará
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          Contact Customer Service

          Ampolla de plást. 500 μg
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          Description
          OverviewPolypeptide neurotoxin known to pass through the blood-brain barrier. Blocks the AHP-type Ca2+-activated K+ channel; does not block the TEA and voltage-sensitive Ca2+-activated K+ channel. Reported to induce neurodegeneration of Purkinje cells in rat brain. Known to induce the secretion of prolactin in a dose-dependent manner.
          Catalogue Number178270
          Brand Family Calbiochem®
          SynonymsCNCKAPETALCARRCQQH-NH₂
          References
          ReferencesMourre, C., et al. 1997. Brain Res. 778, 405.
          Silva, E.G., et al. 1994. Br. J. Pharmacol. 113, 1022.
          Wang, X., et al. 1994. Brain Res. 662, 83.
          Product Information
          CAS number24345-16-2
          ATP CompetitiveN
          FormWhite solid with dark tan cast
          Hill FormulaC₇₉H₁₃₁N₃₁O₂₄S₄
          Chemical formulaC₇₉H₁₃₁N₃₁O₂₄S₄
          Hygroscopic Hygroscopic
          ReversibleN
          Applications
          Biological Information
          Primary TargetAHP-type Ca2+-activated K+ channel
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceH-Cys¹-Asn-Cys³-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys¹¹-Ala-Arg-Arg-Cys¹⁵-Gln-Gln-His-NH₂ (disulfide bonds: 1 → 11; 3 → 15)
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSCD6899900
          Safety Information
          R PhraseR: 20/21/22

          Harmful by inhalation, in contact with skin and if swallowed.
          S PhraseS: 36

          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Acetic acid stock solutions are stable for up to 3 days at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Certificados de análisis

          CargoNúmero de lote
          178270

          Referencias bibliográficas

          Visión general referencias
          Mourre, C., et al. 1997. Brain Res. 778, 405.
          Silva, E.G., et al. 1994. Br. J. Pharmacol. 113, 1022.
          Wang, X., et al. 1994. Brain Res. 662, 83.

          Folleto

          Cargo
          Channel Blockers Technical Bulletin
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-April-2008 RFH
          SynonymsCNCKAPETALCARRCQQH-NH₂
          DescriptionA polypeptide neurotoxin known to pass through the blood-brain barrier. Blocks the AHP-type Ca2+-activated K+ channel; however, it does not block the TEA and voltage-sensitive Ca2+-activated K+ channel. Known to induce the secretion of prolactin in a dose-dependent manner.
          FormWhite solid with dark tan cast
          CAS number24345-16-2
          RTECSCD6899900
          Chemical formulaC₇₉H₁₃₁N₃₁O₂₄S₄
          Peptide SequenceH-Cys¹-Asn-Cys³-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys¹¹-Ala-Arg-Arg-Cys¹⁵-Gln-Gln-His-NH₂ (disulfide bonds: 1 → 11; 3 → 15)
          Purity≥98% by HPLC
          Solubility5% Acetic Acid (2 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Acetic acid stock solutions are stable for up to 3 days at -20°C.
          Toxicity Harmful
          Merck USA index14, 725
          ReferencesMourre, C., et al. 1997. Brain Res. 778, 405.
          Silva, E.G., et al. 1994. Br. J. Pharmacol. 113, 1022.
          Wang, X., et al. 1994. Brain Res. 662, 83.