178273 Aphidicolin - CAS 38966-21-1 - Calbiochem

178273
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical FormulaCAS #
      C₂₀H₃₄O₄ 38966-21-1

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1178273-1MG
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      Disponibilidad a confirmarDisponibilidad a confirmar
      En existencia 
      Suspendido
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      Debe confirmarse disponibilidad
        El resto: se avisará
          El resto: se avisará
          Se avisará
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          Contact Customer Service

          Ampolla de plást. 1 mg
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          Description
          OverviewA cell-permeable tetracyclic diterpene antibiotic that acts as a cell synchronization agent. Blocks the cell cycle at early S-phase. Specific inhibitor of DNA polymerase α and δ in eukaryotic cells and in some viruses. Potentiates apoptosis induced by arabinosyl nucleosides in leukemia cell lines. Also induces apoptosis in HeLa S3 cells, but inhibits vincristine-induced apoptosis in the p53-negative human prostate cancer cell line PC-3. Also available as a 30 mM solution in DMSO (Cat. No. 504744).
          Catalogue Number178273
          Brand Family Calbiochem®
          References
          ReferencesBorner, M.M., et al. 1995. Cancer Res. 55, 2122.
          Poluha, W., et al. 1995. Oncogene 10, 185.
          Urbani, L., et al. 1995. Exp. Cell Res. 219, 159.
          Schimke, R.T., et al. 1994. Philos. Trans. R. Soc. London. B. Biol. Sci. 345, 311.
          Kuwakado, K., et al. 1993. Biochem. Pharmacol. 46, 1909.
          Hubermann, J.A. 1981. Cell 23, 647.
          Product Information
          CAS number38966-21-1
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₀H₃₄O₄
          Chemical formulaC₂₀H₃₄O₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetDNA polymerase α, DNA polymerase δ
          Purity≥98% by TLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSPB9185000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Licencias necesarias

          Título
          CARTA DE USO GENERAL 2016
          PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

          Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Certificados de análisis

          CargoNúmero de lote
          178273

          Referencias bibliográficas

          Visión general referencias
          Borner, M.M., et al. 1995. Cancer Res. 55, 2122.
          Poluha, W., et al. 1995. Oncogene 10, 185.
          Urbani, L., et al. 1995. Exp. Cell Res. 219, 159.
          Schimke, R.T., et al. 1994. Philos. Trans. R. Soc. London. B. Biol. Sci. 345, 311.
          Kuwakado, K., et al. 1993. Biochem. Pharmacol. 46, 1909.
          Hubermann, J.A. 1981. Cell 23, 647.

          Folleto

          Cargo
          Caspases and other Apoptosis Related Tools Brochure
          Tools and Tips for Analyzing Apoptosis
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-April-2008 RFH
          DescriptionA cell-permeable tetracyclic diterpene antibiotic. Cell synchronization agent. Blocks the cell cycle at the early S-phase. Specific inhibitor of DNA polymerase α and δ in eukaryotic cells and in some viruses of animal origin. Potentiates apoptosis induced by arabinosyl nucleosides in leukemia cell lines. Also induces apoptosis in HeLaS3 cells, but inhibits vincristine-induced apoptosis in the p53-negative human prostate cancer cell line PC-3.
          FormWhite solid
          CAS number38966-21-1
          RTECSPB9185000
          Chemical formulaC₂₀H₃₄O₄
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityDMSO (50 mg/ml), Ethanol, or Methanol
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Toxicity Standard Handling
          Merck USA index14, 727
          ReferencesBorner, M.M., et al. 1995. Cancer Res. 55, 2122.
          Poluha, W., et al. 1995. Oncogene 10, 185.
          Urbani, L., et al. 1995. Exp. Cell Res. 219, 159.
          Schimke, R.T., et al. 1994. Philos. Trans. R. Soc. London. B. Biol. Sci. 345, 311.
          Kuwakado, K., et al. 1993. Biochem. Pharmacol. 46, 1909.
          Hubermann, J.A. 1981. Cell 23, 647.