182540 Aromatase Inhibitor I - CAS 331684-05-0 - Calbiochem

182540
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical FormulaCAS #
      C₁₇H₁₁N₃O₄ 331684-05-0

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1182540-1MG
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          Ampolla de plást. 1 mg
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          Description
          OverviewA potent, competitive, nonsteroidal inhibitor of aromatase (P450arom; IC50 = 40 nM for human aromatase). Reported to be more potent than fadrozole in inhibiting aromatase activity. Does not significantly inhibit 17α-hydroxylase.
          Catalogue Number182540
          Brand Family Calbiochem®
          Synonyms4-(Imidazolylmethyl)-1-nitro-9H-9-xanthenone
          References
          ReferencesRecanatini, M., et al. 2001. J. Med. Chem. 44, 672.
          Product Information
          CAS number331684-05-0
          ATP CompetitiveY
          FormWhite solid
          Hill FormulaC₁₇H₁₁N₃O₄
          Chemical formulaC₁₇H₁₁N₃O₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetP450 arom.
          Primary Target IC<sub>50</sub>40 nM against P450arom
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Licencias necesarias

          Título
          CARTA DE USO GENERAL 2016
          PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

          Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Certificados de análisis

          CargoNúmero de lote
          182540

          Referencias bibliográficas

          Visión general referencias
          Recanatini, M., et al. 2001. J. Med. Chem. 44, 672.
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-April-2011 RFH
          Synonyms4-(Imidazolylmethyl)-1-nitro-9H-9-xanthenone
          DescriptionA potent, selective, nonsteroidal, competitive inhibitor of aromatase (P450arom) (IC50 = 40 nM for human aromatase) Reported to be more potent than fadrozole in inhibiting aromatase activity. Does not significantly inhibit human 17α-hydroxylase (P450 17) (4% inhibition at 2.5 µM).
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number331684-05-0
          Chemical formulaC₁₇H₁₁N₃O₄
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (25 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesRecanatini, M., et al. 2001. J. Med. Chem. 44, 672.