182800 Ascomycin, Streptomyces hygroscopicus - CAS 11011-38-4 - Calbiochem

182800
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical FormulaCAS #
      C₄₃H₆₉NO₁₂ 11011-38-4

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1182800-1MG
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          Description
          OverviewAn ethyl analog of FK506 with similar immunosuppressant properties. Acts by binding to immunophilins. Inhibits the synthesis of Th-1 and Th-2 type cytokines in target cells.
          Catalogue Number182800
          Brand Family Calbiochem®
          SynonymsImmunomycin, FR-900520
          References
          ReferencesPaul, C., et al. 2000. Expert Opin. Invest. Drugs 9, 69.
          Kawai, M., et al. 1993. FEBS Lett. 316, 107.
          Pilot-Matias, T.J., et al. 1993. Gene 128, 219.
          Shafiee, A., et al. 1993. J. Antibiot. 46, 1397.
          Petros, A.M., et al. 1992. J. Med. Chem. 35, 2467.
          Product Information
          CAS number11011-38-4
          ATP CompetitiveN
          FormWhite crystalline solid
          Hill FormulaC₄₃H₆₉NO₁₂
          Chemical formulaC₄₃H₆₉NO₁₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Biological activityFully active via yeast rotamase (FK 506 binding protein) inhibition
          Primary TargetImmunophilins
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSCI7570000
          Safety Information
          R PhraseR: 20/21/22-36/37/38

          Harmful by inhalation, in contact with skin and if swallowed.
          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 3 days at -20°C. Anhydrous DMSO stock solutions are stable for up to 1 month -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ascomycin, Streptomyces hygroscopicus - CAS 11011-38-4 - Calbiochem Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Ascomycin, Streptomyces hygroscopicus - CAS 11011-38-4 - Calbiochem Certificados de análisis

          CargoNúmero de lote
          182800

          Referencias bibliográficas

          Visión general referencias
          Paul, C., et al. 2000. Expert Opin. Invest. Drugs 9, 69.
          Kawai, M., et al. 1993. FEBS Lett. 316, 107.
          Pilot-Matias, T.J., et al. 1993. Gene 128, 219.
          Shafiee, A., et al. 1993. J. Antibiot. 46, 1397.
          Petros, A.M., et al. 1992. J. Med. Chem. 35, 2467.

          Citas

          Título
        • Brian Adams, et al. (2005) A novel class of dual-family immunophilins. Journal of Biological Chemistry 280, 24308-24314.
        • Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-April-2008 RFH
          SynonymsImmunomycin, FR-900520
          DescriptionEthyl analog of FK-506 that possesses the same potent immunosuppressive properties as the parent compound. Inhibition of the Ca2+/calmodulin activated phosphatase calcineurin (IC50 = 10 nM) by the ascomycin/FK-506 binding protein complex is believed to be important in the mechanism of immunosuppression. Acts by binding immumophilins.
          FormWhite crystalline solid
          CAS number11011-38-4
          RTECSCI7570000
          Chemical formulaC₄₃H₆₉NO₁₂
          Structure formulaStructure formula
          Purity≥90% by HPLC
          Biological activityFully active via yeast rotamase (FK 506 binding protein) inhibition
          SolubilityDMSO (1 mg/ml) or Ethanol (1 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 3 days at -20°C. Anhydrous DMSO stock solutions are stable for up to 1 month -20°C.
          Toxicity Harmful
          ReferencesPaul, C., et al. 2000. Expert Opin. Invest. Drugs 9, 69.
          Kawai, M., et al. 1993. FEBS Lett. 316, 107.
          Pilot-Matias, T.J., et al. 1993. Gene 128, 219.
          Shafiee, A., et al. 1993. J. Antibiot. 46, 1397.
          Petros, A.M., et al. 1992. J. Med. Chem. 35, 2467.
          Citation
        • Brian Adams, et al. (2005) A novel class of dual-family immunophilins. Journal of Biological Chemistry 280, 24308-24314.