189484 Autocamtide-2 Related Inhibitory Peptide II - Calbiochem

189484
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical Formula
      C₇₁H₁₂₃N₂₃O₁₉

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1189484-1MG
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          Ampolla de plást. 1 mg
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          Description
          OverviewAn AIP (Cat. No. 189480) analog, in which Ala3 and Val10 are replaced with Lys and Phe respectively. Acts as a highly specific, potent inhibitor of calmodulin-dependent protein kinase II (CaMKII; IC50 = 4.1 nM). Displays ~10-fold greater potency than AIP. Inhibits PKC at higher concentrations (IC50 = 1 µM) and does not affect the activities of CaMK IV and PKA (IC50 > 100 µM).
          Catalogue Number189484
          Brand Family Calbiochem®
          SynonymsA3K/V10F-AIP, AIP-II, KKKLRRQEAFDAL
          References
          ReferencesIshida, A., et al. 1998. FEBS Lett. 427, 115.
          Product Information
          ATP CompetitiveN
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₇₁H₁₂₃N₂₃O₁₉
          Chemical formulaC₇₁H₁₂₃N₂₃O₁₉
          Hygroscopic Hygroscopic
          ReversibleN
          Applications
          Biological Information
          Primary TargetCAM Kinase-2
          Primary Target IC<sub>50</sub>4.1 nM
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceH-Lys-Lys-Lys-Leu-Arg-Arg-Gln-Glu-Ala-Phe-Asp-Ala-Leu-OH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Autocamtide-2 Related Inhibitory Peptide II - Calbiochem Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Autocamtide-2 Related Inhibitory Peptide II - Calbiochem Certificados de análisis

          CargoNúmero de lote
          189484

          Referencias bibliográficas

          Visión general referencias
          Ishida, A., et al. 1998. FEBS Lett. 427, 115.
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-April-2008 RFH
          SynonymsA3K/V10F-AIP, AIP-II, KKKLRRQEAFDAL
          DescriptionAn autocamtide-2 related inhibitory peptide (AIP) analog in which Ala3 and Val10 have been replaced with Lys and Phe, respectively. Acts as a highly specific, potent inhibitor of calmodulin-dependent protein kinase II (CaMKII) (IC50 = 4.1 nM). Displays ~10-fold greater potency than AIP (Cat. No. 189480). Inhibits PKC at higher concentrations (IC50 = 1 µM), but does not affect the activities of CaMKIV or PKA (IC50 >100 µM).
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₇₁H₁₂₃N₂₃O₁₉
          Peptide SequenceH-Lys-Lys-Lys-Leu-Arg-Arg-Gln-Glu-Ala-Phe-Asp-Ala-Leu-OH
          Purity≥97% by HPLC
          SolubilityDMSO (5 mg/ml) or H₂O (1 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesIshida, A., et al. 1998. FEBS Lett. 427, 115.