189490 Autophagy Inhibitor, 3-MA - CAS 5142-23-4 - Calbiochem

189490
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical FormulaCAS #
      C₆H₇N₅ 5142-23-4

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1189490-50MG
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          Ampolla de plást. 50 mg
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          Description
          OverviewA widely used cell-permeable autophagic sequestration blocker that effectly protects cerebellar granule cells from apoptosis following serum/potassium deprivation. Although a known class III PI3K inhibitor (IC50 = 4.5 mM in cell-free enzymatic assays), 3-MA exhibits quite distinct pharmacological properties from those of two other PI3K inhibitors, LY 294002 (Cat. Nos. 440202 and 440204) and Wortmannin (Cat. No. 681675)
          Catalogue Number189490
          Brand Family Calbiochem®
          Synonyms3-Methyladenine
          References
          ReferencesCanu, N., et al. 2005. J. Neurochem. 92, 1228.
          Hirosako, K., et al. 2004. Biochem. Biophys. Res. Commun. 316, 845.
          Beugnet, A., et al. 2003. Biochem. J. 372, 555.
          Eskelinen, E.L., et al. 2002. Traffic 3, 878.
          Petiot, A., et al. 2000. J. Biol. Chem. 275, 992.
          Seglen, P.O. and Gordon, P.B., 1982. Proc. Natl. Acad. Sci. USA 79, 1889.
          Product Information
          CAS number5142-23-4
          FormWhite to faint yellow powder
          Hill FormulaC₆H₇N₅
          Chemical formulaC₆H₇N₅
          Structure formula ImageStructure formula Image
          Applications
          ApplicationAutophagy Inhibitor, 3-MA, CAS 5142-23-4, is a cell-permeable autophagic sequestration blocker that protects cerebellar granule cells from apoptosis following serum/potassium deprivation.
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Licencias necesarias

          Título
          CARTA DE USO GENERAL 2016
          PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

          Autophagy Inhibitor, 3-MA - CAS 5142-23-4 - Calbiochem Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Autophagy Inhibitor, 3-MA - CAS 5142-23-4 - Calbiochem Certificados de análisis

          CargoNúmero de lote
          189490

          Referencias bibliográficas

          Visión general referencias
          Canu, N., et al. 2005. J. Neurochem. 92, 1228.
          Hirosako, K., et al. 2004. Biochem. Biophys. Res. Commun. 316, 845.
          Beugnet, A., et al. 2003. Biochem. J. 372, 555.
          Eskelinen, E.L., et al. 2002. Traffic 3, 878.
          Petiot, A., et al. 2000. J. Biol. Chem. 275, 992.
          Seglen, P.O. and Gordon, P.B., 1982. Proc. Natl. Acad. Sci. USA 79, 1889.
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision14-May-2012 JSW
          Synonyms3-Methyladenine
          DescriptionA widely used cell-permeable autophagic sequestration blocker that effectly protects cerebellar granule cells from apoptosis following serum/potassium deprivation. Although a known class III PI3K inhibitor (IC50 = 4.5 mM in cell-free enzymatic assays), 3-MA exhibits quite distinct pharmacological properties from those of two other PI3K inhibitors, LY 294002 (Cat. Nos. 440202 and 440204) and Wortmannin (Cat. No. 681675)
          FormWhite to faint yellow powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number5142-23-4
          Chemical formulaC₆H₇N₅
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml) or H₂O (5 mg/ml). In applications where high working concentrations are necessary (e.g. 10 mM), the use of a pre-made stock solution may result in the introduction of higher than desired solvent (e.g., DMSO) into the experimental systems. In such cases, it is recommended that the solid compound be weighed out at the time of use and reconstituted directly into the solutions used in the experimental system (buffers, media, etc.). Vortexing may be required for complete solubilization in water.
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesCanu, N., et al. 2005. J. Neurochem. 92, 1228.
          Hirosako, K., et al. 2004. Biochem. Biophys. Res. Commun. 316, 845.
          Beugnet, A., et al. 2003. Biochem. J. 372, 555.
          Eskelinen, E.L., et al. 2002. Traffic 3, 878.
          Petiot, A., et al. 2000. J. Biol. Chem. 275, 992.
          Seglen, P.O. and Gordon, P.B., 1982. Proc. Natl. Acad. Sci. USA 79, 1889.