124038 InSolution™ Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem

124038
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical FormulaCAS #
      C₁₃H₁₆N₆O₄ 35943-35-2

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1124038-2MG
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      Disponibilidad a confirmarDisponibilidad a confirmar
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      Suspendido
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        El resto: se avisará
          El resto: se avisará
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          Frasco de vidrio 2 mg
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          Description
          OverviewA cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3 by targeting an Akt effector molecule other than PI 3-K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥60% in cell proliferation at 20 µM) and in vivo (≥80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.).
          Catalogue Number124038
          Brand Family Calbiochem®
          References
          ReferencesKarst, A., et al. 2006. Cancer Res. 66, 9225.
          Yang, L., et al. 2004. Cancer Res. 64, 4394.
          Product Information
          CAS number35943-35-2
          FormLiquid
          FormulationA 2 mg/312 µl solution of Akt Inhibitor V, Triciribine (Cat. No. 124012) in DMSO.
          Hill FormulaC₁₃H₁₆N₆O₄
          Chemical formulaC₁₃H₁₆N₆O₄
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSRY8455000
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Irritant
          Storage ≤ -70°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing intitial thaw, aliquot and freeze (-70°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Certificados de análisis

          CargoNúmero de lote
          124038

          Referencias bibliográficas

          Visión general referencias
          Karst, A., et al. 2006. Cancer Res. 66, 9225.
          Yang, L., et al. 2004. Cancer Res. 64, 4394.
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision16-January-2012 RFH
          DescriptionA cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3 by targeting an Akt effector molecule other than PI 3-K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥60% in cell proliferation at 20 µM) and in vivo (≥80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.).
          FormLiquid
          FormulationA 2 mg/312 µl solution of Akt Inhibitor V, Triciribine (Cat. No. 124012) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number35943-35-2
          RTECSRY8455000
          Chemical formulaC₁₃H₁₆N₆O₄
          Structure formulaStructure formula
          Purity≥95% by HPLC
          Storage ≤ -70°C
          Hygroscopic
          Protect from light
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing intitial thaw, aliquot and freeze (-70°C).
          Toxicity Irritant
          ReferencesKarst, A., et al. 2006. Cancer Res. 66, 9225.
          Yang, L., et al. 2004. Cancer Res. 64, 4394.