119113 Luciferase Inhibitor I - CAS 352341-26-5 - Calbiochem

119113
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical FormulaCAS #
      C₁₄H₁₁N₃O₂ 352341-26-5

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1119113-5MG
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      Disponibilidad a confirmarDisponibilidad a confirmar
      En existencia 
      Suspendido
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      Debe confirmarse disponibilidad
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          El resto: se avisará
          Se avisará
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          Frasco de vidrio 5 mg
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          Description
          OverviewA 3,5-diaryl-oxadiazole compound that acts as an inhibitor against the ATP-dependent Photuris pennsylvanica (lucPpe) and Photinus pyralis (lucPpy) luciferase activity (IC50 = 0.08 and 2.8 µM, respectively, with 10 µM ATP, 10 µM luciferin, and 10 nM respective enzyme) and effectively inhibits lucPpe-based commercial luciferase-luciferin formulations (IC50 = 5, 13.5, and 12.7 µM against Promega's Kinase-Glo®, Kinase-Glo® Plus, and Kinase-Glo® Max, respectively, at a 3-fold formulation dilution and 6.77 µM ATP). Unlike Luciferase Inhibitor II (Cat. No. 119114), Luciferase Inhibitor I is noncompetitive with respect to either luciferin or ATP.
          Catalogue Number119113
          Brand Family Calbiochem®
          Synonyms2-(5-(2-Methoxyphenyl)-1,2,4-oxadiazol-3-yl)pyridine
          References
          ReferencesAuld, D.S., et al. 2009. J. Med. Chem. 52, 1450.
          Auld, D.S., et al. 2008. J. Med. Chem. 51, 2372.
          Product Information
          CAS number352341-26-5
          DeclarationMarketed by Promega Corp. under the registered trademarks.
          FormOff-white solid
          Hill FormulaC₁₄H₁₁N₃O₂
          Chemical formulaC₁₄H₁₁N₃O₂
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Licencias necesarias

          Título
          CARTA DE USO GENERAL 2016
          PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

          Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Certificados de análisis

          CargoNúmero de lote
          119113

          Referencias bibliográficas

          Visión general referencias
          Auld, D.S., et al. 2009. J. Med. Chem. 52, 1450.
          Auld, D.S., et al. 2008. J. Med. Chem. 51, 2372.
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision04-April-2011 RFH
          Synonyms2-(5-(2-Methoxyphenyl)-1,2,4-oxadiazol-3-yl)pyridine
          DescriptionA 3,5-diaryl-oxadiazole compound that acts as an inhibitor against the ATP-dependent Photuris pennsylvanica (lucPpe) and Photinus pyralis (lucPpy) luciferase activity (IC50 = 0.08 and 2.8 µM, respectively, with 10 µM ATP, 10 µM luciferin, and 10 nM respective enzyme) and effectively inhibits lucPpe-based commercial luciferase-luciferin formulations (IC50 = 5, 13.5, and 12.7 µM against Promega's Kinase-Glo®, Kinase-Glo® Plus, and Kinase-Glo® Max, respectively, at a 3-fold formulation dilution and 6.77 µM ATP). Unlike Luciferase Inhibitor II (Cat. No. 119114), Luciferase Inhibitor I is noncompetitive with respect to either luciferin or ATP.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number352341-26-5
          Chemical formulaC₁₄H₁₁N₃O₂
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (50 mg/ml) or Ethanol (25 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesAuld, D.S., et al. 2009. J. Med. Chem. 52, 1450.
          Auld, D.S., et al. 2008. J. Med. Chem. 51, 2372.