HAGE1MAG-20K MILLIPLEX® MAP Human Aging Magnetic Bead Panel 1 - Metabolism Multiplex Assay

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Descripción

Replacement Information

Tabla espec. clave

Analytes AvailableSpecies ReactivityKey ApplicationsDetection Methods
CTACK, FGF-21, GDF-11, GDF-15, GnRH, IL-6, IL-10, IL-18, Jag1, Leptin, Wnt-3a H Mplex Luminex xMAP
Description
Catalogue NumberHAGE1MAG-20K
Trade Name
  • MILLIPLEX
DescriptionMILLIPLEX® MAP Human Aging Magnetic Bead Panel 1 - Metabolism Multiplex Assay
OverviewThe MILLIPLEX® MAP Human Aging Panel 1 is an 11-plex kit to be used for the simultaneous quantification of any or all of the following analytes in serum, plasma, and in vitro samples: C-C motif chemokine 27 (CTACK/CCL27), Fibroblast growth factor 21 (FGF-21), Growth/differentiation factor 11 (GDF-11), Growth/differentiation factor 15 (GDF-15), Gonadoliberin (GnRH), Interleukin-6 (IL-6), Interleukin-10 (IL-10), Interleukin 18 (IL-18), Jagged 1 protein (Jag1), Leptin, and Wnt3a protein (Wnt-3a).
Note: IL-10 is recommended for in vitro sample use only; do not test IL-10 in serum or plasma samples.
Background InformationAging associated physiological changes and the pathological consequences of these changes make the elderly population vulnerable to many chronic diseases, including diabetes, cancers, cardiovascular and neurodegenerative diseases, etc. The complexity of the aging process has stimulated intensive research over the years. Aberrant glucose metabolism, elevated chronic inflammatory levels, progressive cellular senescence and other pathophysiological conditions have proven to be associated with the aging process.
The MILLIPLEX® MAP Human Aging Panel 1 covers multifaceted biomarkers of aging-related conditions. Monitoring these novel biomarkers would help researchers to understand the basic mechanisms that drive aging and eventually lead to improved clinical interventions for extending the human health span.
References
Product Information
Detection methodLuminex xMAP
ConfigurationDesign your multiplex kit by choosing available analytes within this panel.
Precision, %
  • CTACK: Intra-assay <5% CV; Inter-assay <10%
  • FGF-21: Intra-assay <5% CV; Inter-assay <15%
  • GDF-11: Intra-assay <10% CV; Inter-assay <15%
  • GDF-15: Intra-assay <10% CV; Inter-assay <10%
  • GnRH: Intra-assay <10% CV; Inter-assay <15%
  • IL-6: Intra-assay <5% CV; Inter-assay <10%
  • IL-10: Intra-assay <5% CV; Inter-assay <15%
  • IL-18: Intra-assay <5% CV; Inter-assay <15%
  • Jag1: Intra-assay <10% CV; Inter-assay <15%
  • Leptin: Intra-assay <5% CV; Inter-assay <10%
  • Wnt-3a: Intra-assay <5% CV; Inter-assay <10%
Panel TypeMAGNETIC Metabolism
Applications
ApplicationThe analytes available for this multiplex kit are: CTACK/CCL27, FGF-21, GDF-11, GDF-15, Gonadoliberin (GnRH), IL-6, IL-10, IL-18, Jagged 1 protein (Jag1), Leptin, & Wnt3a protein (Wnt-3a).
Key Applications
  • Multiplexing
Application NotesFor optimal sensitivity, use an overnight (16-18 hour) incubation. A two hour incubation can also be used. Serum and plasma samples require (recommend) a 1:2 dilution with Assay Buffer. Tissue culture supernatants may be run neat or appropriately diluted in control medium. Each well requires 25 μL of sample, standard or control.
Biological Information
SpecificityCross-reactivity between the antibodies and any of the other analytes in this panel is non-detectable or negligible.
Species Reactivity
  • Human
Analytes Available
  • CTACK
  • FGF-21
  • GDF-11
  • GDF-15
  • GnRH
  • IL-6
  • IL-10
  • IL-18
  • Jag1
  • Leptin
  • Wnt-3a
Assay PanelEverything you need in a single kit.
Cross ReactivityThe GDF-11 antibody pair has 2.3% cross-reactivity to Myostatin/GDF-8.
Accuracy
  • CTACK/CCL27 93%
  • FGF-21 95%
  • GDF-11 88%
  • GDF-15 94%
  • GnRH 84%
  • IL-6 93%
  • IL-10 98%
  • IL-18 96%
  • Jag1 98%
  • Leptin 96%
  • Wnt-3a 99%
Physicochemical Information
Sensitivity
  • MinDC+2SD
  • CTACK: 17.58 pg/mL
  • FGF-21: 2.39 pg/mL
  • GDF-11: 0.72 ng/mL
  • GDF-15: 2.12 pg/mL
  • GnRH: 13.43 pg/mL
  • IL-6: 4.19 pg/mL
  • IL-10: 35.92 pg/mL
  • IL-18: 4.16 pg/mL
  • Jag1: 1.75 ng/mL
  • Leptin: 14.61 pg/mL
  • Wnt-3a: 0.52 ng/mL
Linearity of DilutionContact technical support for this information
Standard Curve Range
  • CTACK: 20 - 80,000 pg/mL
  • FGF-21: 4 - 15,000 pg/mL
  • GDF-11: 1 - 4,000 ng/mL
  • GDF-15: 2 - 10,000 pg/mL
  • GnRH: 10 - 40,000 pg/mL
  • IL-6: 2 - 10,000 pg/mL
  • IL-10: 39 - 160,000 pg/mL
  • IL-18: 2 - 10,000 pg/mL
  • Jag1: 2 - 8,000 ng/mL
  • Leptin: 49 - 200,000 pg/mL
  • Wnt-3a: 0.5 - 2,000 ng/mL
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsRecommended storage for kit components is 2 - 8°C.
Packaging Information
Material Size96-well plate
Transport Information
Supplemental Information
Specifications

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Categorías

Life Science Research > Protein Detection and Quantification > Immunoassays > Multiplexed Immunoassays > Milliplex MAP Assay Products > Configurable Kits