116805 | PKA Inhibitor 5-24 - CAS 99534-03-9 - Calbiochem

116805
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical FormulaCAS #
      C₉₄H₁₄₈N₃₂O₃₁ 99534-03-9

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1116805-500UG
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      Disponibilidad a confirmarDisponibilidad a confirmar
      En existencia 
      Suspendido
      Cantidades limitadas disponibles
      Debe confirmarse disponibilidad
        El resto: se avisará
          El resto: se avisará
          Se avisará
          Póngase en contacto con el Servicio de Atención al Cliente

          Ampolla de plást. 500 μg
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          Description
          OverviewA potent synthetic peptide that is a competitive inhibitor of protein kinase A (Ki = 2.3 nM). Its sequence is derived from the heat-stable skeletal muscle inhibitor protein of PKA. Binds to the catalytic subunit of PKA and displaces the regulatory subunit. Mimics the protein substrate by binding to the catalytic site via the arginine-cluster basic substrate.
          Catalogue Number116805
          Brand Family Calbiochem®
          SynonymsProtein Kinase A Inhibitor 5-24, H-TTYADFIASGRTGRRNAIHD, PKA Inhibitor IV
          References
          ReferencesKnighton, D.R., et al. 1991. Science 253, 525.
          Cheng, H.C., et al. 1986. J. Biol. Chem. 261, 989.
          Rusine, T., et al. 1986. J. Cell Biol. 102, 1630.
          Wong, Y.S., et al. 1986. J. Biol. Chem. 12089.
          Product Information
          CAS number99534-03-9
          ATP CompetitiveN
          FormLyophilized
          FormulationSupplied as a trifluoroacetate salt. Sold on the basis of peptide content.
          Hill FormulaC₉₄H₁₄₈N₃₂O₃₁
          Chemical formulaC₉₄H₁₄₈N₃₂O₃₁
          Hygroscopic Hygroscopic
          ReversibleN
          Sold on the basis of peptide contentY
          Applications
          Biological Information
          Primary TargetPKA
          Primary Target K<sub>i</sub>2.3 nM for protein kinase A
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide ContentY
          Peptide SequenceH-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp-OH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Certificados de análisis

          CargoNúmero de lote
          116805

          Referencias bibliográficas

          Visión general referencias
          Knighton, D.R., et al. 1991. Science 253, 525.
          Cheng, H.C., et al. 1986. J. Biol. Chem. 261, 989.
          Rusine, T., et al. 1986. J. Cell Biol. 102, 1630.
          Wong, Y.S., et al. 1986. J. Biol. Chem. 12089.
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-April-2008 RFH
          SynonymsProtein Kinase A Inhibitor 5-24, H-TTYADFIASGRTGRRNAIHD, PKA Inhibitor IV
          DescriptionPeptide corresponding to the active site on the skeletal muscle inhibitor protein. Competitive inhibitor of protein kinase A (Ki = 2.3 nM).
          FormLyophilized
          FormulationSupplied as a trifluoroacetate salt. Sold on the basis of peptide content.
          CAS number99534-03-9
          Chemical formulaC₉₄H₁₄₈N₃₂O₃₁
          Peptide SequenceH-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp-OH
          Purity≥95% by HPLC
          SolubilityH₂O (1 mg/ml). Sonication or the addition of a few drops of dilute acid (10 mM HCl) may be necessary to achieve complete solubilization.
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
          Toxicity Standard Handling
          ReferencesKnighton, D.R., et al. 1991. Science 253, 525.
          Cheng, H.C., et al. 1986. J. Biol. Chem. 261, 989.
          Rusine, T., et al. 1986. J. Cell Biol. 102, 1630.
          Wong, Y.S., et al. 1986. J. Biol. Chem. 12089.