14-558 PI3 Kinase (p120γ), 20 µg

14-558
20 µg  Also available in 250μg size as catalog # 14-558M - Call for pricing and availability.
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      Overview

      Replacement Information
      Description
      Catalogue Number14-558
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionPI3 Kinase (p120γ), 20 µg
      OverviewN-terminal His6-tagged recombinant full-length human PI 3-kinase (p120γ).
      References
      Product Information
      Applications
      ApplicationFor use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceExpressed by baculovirus in Sf21 insect cells
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.
      Gene Symbol
      • PIK3CG
      • p110-gamma
      • PI3-kinase
      • PIK3
      • PI3K
      • PI3Kgamma
      • PTDINS-3-kinase
      • PI3CG
      • p120-PI3K
      Protein TargetPI3Kγ
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyPI3K/PI4K
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P48736 # 3-phosphorylates the cellular phosphoinositide PtdIns- 4,5-biphosphate (PtdIns(4,5)P2) to produce PtdIns-3, 4,5- triiphosphate (PtdIns(3,4,5)P3). Links G-protein coupled receptor activation to the secondary messenger PtdIns(3,4,5)P3 production.
      SIZE: 1102 amino acids; 126454 Da
      SUBUNIT: Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit.
      TISSUE SPECIFICITY: Pancreas, skeletal muscle, liver and heart.
      SIMILARITY: SwissProt: P48736 ## Belongs to the PI3/PI4-kinase family. & Contains 1 PI3K/PI4K domain.
      Molecular Weight130kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated in the PIProfiler.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size20 µg
      Material PackageAlso available in 250μg size as catalog # 14-558M - Call for pricing and availability.
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      PI3 Kinase (p120γ), 20 µg SDS

      Title

      Safety Data Sheet (SDS) 

      PI3 Kinase (p120γ), 20 µg Certificates of Analysis

      TitleLot Number
      PI3 Kinase (p120#947;) - 1940422-B1940422-B
      PI3 Kinase (p120#947;) - 2017936-A2017936-A
      PI3 Kinase (p120#947;) - 2017936-C2017936-C
      PI3 Kinase (p120#947;) - 2017936-E2017936-E
      PI3 Kinase (p120#947;) - 2017936-F2017936-F
      PI3 Kinase (p120#947;) - 2127542-B2127542-B
      PI3 Kinase (p120#947;) - 2189229-A2189229-A
      PI3 Kinase (p120γ) - 1940422-C1940422-C
      PI3 Kinase (p120γ) - 2017936-G2017936-G
      PI3 Kinase (p120γ) - 2127542-C2127542-C

      References

      Reference overviewPub Med ID
      Nonradioactive methods for the assay of phosphoinositide 3-kinases and phosphoinositide phosphatases and selective detection of signaling lipids in cell and tissue extracts.
      Gray, Alexander, et al.
      Anal. Biochem., 313: 234-45 (2003)  2003

      Show Abstract
      12605860 12605860

      Technical Info

      Title
      Unlocking the Mystery of Cancer: Do the Mutant p110α Subunits of PI3-Kinase Hold the Key?

      Data Sheet

      Title
      PI 3-Kinase HTRF Assay

      Related Products & Applications

      Alternative Packsize

      Catalogue Number Description  
      14-558M PI3 Kinase (p120γ), 250 µg Show Pricing & Availability

      Product Families

      Categories

      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases
      Life Science Research > Proteins and Enzymes > Purified Kinases