AB3239 Anti-Myostatin Antibody, Near CT

AB3239
50 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MICC, IHC, IH(P), WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB3239
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Myostatin Antibody, Near CT
      Alternate Names
      • growth differentiation factor 8
      Background InformationMyostatin (GDF8) is expressed uniquely in human skeletal muscle as a 12 kDa mature glycoprotein consisting of 113 amino acid residues and secreted into plasma. Myostatin is a member of the transforming growth factor ß superfamily of secreted growth and differentiation factors that is essential for proper regulation of skeletal muscle mass. Studies have shown that myostatin could play an important role in cardiac development and physiology.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Skeletal muscle
      PresentationAffinity purified rabbit polyclonal in buffer containing Tris-citrate/phosphate, pH 7-8 containing 0.1% sodium azide
      Applications
      ApplicationAnti-Myostatin Antibody, Near C-terminus is an antibody against Myostatin for use in IC, IH, IH(P) & WB.
      Key Applications
      • Immunocytochemistry
      • Immunohistochemistry
      • Immunohistochemistry (Paraffin)
      • Western Blotting
      Application NotesImmunohistochemistry:
      1:250-1:1,000

      Western blot:
      A 1:500-1:5,000 dilution of a previous lot was used in western blot. Recognizes a band migrating at approximately 26 kDa.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptide corresponding to a portion of human Myostatin. Synthetic peptide corresponding to amino acids 349-364 of human Myostatin.
      EpitopeNear C-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityMyostatin (Growth and Differentiation Factor 8, GDF8). Recognizes the mature forms of myostatin.
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteHuman and mouse. Other species have not been tested.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth.
      Gene Symbol
      • MSTN
      • GDF-8
      • GDF8
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O14793 # Acts specifically as a negative regulator of skeletal muscle growth.
      SIZE: 375 amino acids; 42750 Da
      SUBUNIT: Homodimer; disulfide-linked (By similarity). Interacts with WFIKKN2, leading to inhibit its activity.
      SUBCELLULAR LOCATION: Secreted.
      SIMILARITY: SwissProt: O14793 ## Belongs to the TGF-beta family.
      Molecular Weight26 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by immunohistochemistry(paraffin) on mouse muscle.

      Immunohistochemistry(paraffin):
      Optimal Staining Without Epitope Retrieval: Mouse Muscle
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 6 months at 2-8ºC from date of receipt. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Myostatin Antibody, Near CT SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Myostatin Antibody, Near CT Certificates of Analysis

      TitleLot Number
      Anti-Myostatin, Near C-terminus - 19836741983674
      Anti-Myostatin, Near C-terminus - 20263692026369
      Anti-Myostatin, Near C-terminus - LV1544996LV1544996
      Anti-Myostatin, Near C-terminus - NG1849462NG1849462
      Anti-Myostatin, Near C-terminus - NG1869822NG1869822
      Anti-Myostatin, Near C-terminus - NMM1613226NMM1613226
      Anti-Myostatin, Near C-terminus - NMM1644083NMM1644083
      Anti-Myostatin, Near C-terminus - NMM1679628NMM1679628
      Anti-Myostatin, Near C-terminus - NMM1698683NMM1698683
      Anti-Myostatin, Near C-terminus - NMM1721978NMM1721978

      References

      Reference overviewApplicationPub Med ID
      Muscle atrophy reversed by growth factor activation of satellite cells in a mouse muscle atrophy model.
      Hauerslev, S; Vissing, J; Krag, TO
      PloS one  9  e100594  2014

      Show Abstract
      24963862 24963862
      Highly specific detection of myostatin prodomain by an immunoradiometric sandwich assay in serum of healthy individuals and patients.
      Breitbart, A; Scharf, GM; Duncker, D; Widera, C; Gottlieb, J; Vogel, A; Schmidt, S; Brandes, G; Heuft, HG; Lichtinghagen, R; Kempf, T; Wollert, KC; Bauersachs, J; Heineke, J
      PloS one  8  e80454  2013

      Show Abstract
      24260393 24260393
      A Nitrate Ester of Sedative Alkyl Alcohol Improves Muscle Function and Structure in a Murine Model of Duchenne Muscular Dystrophy.
      Wang, Guqi and Lu, Qilong
      Mol. Pharm., (2013)  2013

      Show Abstract
      23924275 23924275
      Protein turnover and cellular stress in mildly and severely affected muscles from patients with limb girdle muscular dystrophy type 2I.
      Hauerslev, S; Sveen, ML; Vissing, J; Krag, TO
      PloS one  8  e66929  2013

      Show Abstract
      23840556 23840556
      Greater insulin sensitivity in calorie restricted rats occurs with unaltered circulating levels of several important myokines and cytokines.
      Sharma, N; Castorena, CM; Cartee, GD
      Nutrition & metabolism  9  90  2012

      Show Abstract
      Western Blotting23067400 23067400
      Myostatin is associated with age-related human muscle stem cell dysfunction.
      McKay, BR; Ogborn, DI; Bellamy, LM; Tarnopolsky, MA; Parise, G
      FASEB journal : official publication of the Federation of American Societies for Experimental Biology  26  2509-21  2012

      Show Abstract
      22403007 22403007
      Differential expression of mature microRNAs involved in muscle maintenance of hibernating little brown bats, Myotis lucifugus: a model of muscle atrophy resistance.
      Kornfeld, SF; Biggar, KK; Storey, KB
      Genomics, proteomics & bioinformatics  10  295-301  2012

      Show Abstract
      23200139 23200139
      Immunolocalization of myostatin (GDF-8) following musculoskeletal injury and the effects of exogenous myostatin on muscle and bone healing.
      Elkasrawy, M; Immel, D; Wen, X; Liu, X; Liang, LF; Hamrick, MW
      The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society  60  22-30  2012

      Show Abstract
      22205678 22205678
      Myostatin expression during human muscle hypertrophy and subsequent atrophy: increased myostatin with detraining.
      J G Jespersen,A Nedergaard,L L Andersen,P Schjerling,J L Andersen
      Scandinavian journal of medicine & science in sports  21  2011

      Show Abstract
      19903317 19903317
      Elevation of myostatin and FOXOs in prolonged muscular impairment induced by eccentric contractions in rat medial gastrocnemius muscle.
      Eisuke Ochi,Tatsuro Hirose,Kenji Hiranuma,Seok-Ki Min,Naokata Ishii,Koichi Nakazato
      Journal of applied physiology (Bethesda, Md. : 1985)  108  2010

      Show Abstract
      19959771 19959771

      Data Sheet

      Title
      Anti-Myostatin, Near C-terminus - Data Sheet

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies