ABE302 | Anti-ATDC Antibody

ABE302
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, IPRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABE302
      DescriptionAnti-ATDC Antibody
      Alternate Names
      • Ataxia telangiectasia group D-associated protein
      • tripartite motif containing protein 29
      Background InformationAtaxia telangiectasia group D-complementing (ATDC) protein, also known as tripartite motif containing protein 29 (TRIM29), belongs to the TRIM protein family. Studies have shown that ATDC may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. The ATDC gene is located at 11q23 where loss of heterozygosity has been observed in many kinds of cancers; underexpression of ATDC has been reported in breast and prostate cancer. ATDC may also complement the radiosensitivity defect of ataxia telangiectasia phenotype.
      References
      Product Information
      FormatAffinity Purified
      Control
      • RAW 264.7 cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-ATDC Antibody is a Rabbit Polyclonal Antibody for detection of ATDC also known as Ataxia telangiectasia group D-associated protein & has been validated in WB & IP.
      Key Applications
      • Western Blotting
      • Immunoprecipitation
      Application NotesImmunoprecipitation Analysis: A representative lot was used by an independent laboratory in IP. (Yuan, Z., et al. (2010). J Biol Chem. 285(50):39329-39338.)
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to a region within amino acides 565 to 595 of human ATDC .
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype. [provided by RefSeq, Jul 2008].
      Gene Symbol
      • TRIM29
      • ATDC
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: It is able to complement the radiosensitivity defect of an ataxia telangiectasia (AT) fibroblast cell line.

      SUBUNIT STRUCTURE: Interacts with VIM and HINT1.

      SUBCELLULAR LOCATION: Cytoplasm. Note: Colocalizes with intermediate filaments.

      TISSUE SPECIFICITY: Expressed in placenta, prostate and thymus.

      PTM: Constitutively phosphorylated by PKC on serine/threonine in A431 cells.

      SEQUENCE SIMILARITIES: Contains 1 B box-type zinc finger.
      Molecular Weight~66 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in RAW 264.7 cell lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected ATDC on 10 µg of RAW 264.7 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications