ABC839 | Anti-ATR Antibody

ABC839
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHC, ICCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABC839
      DescriptionAnti-ATR Antibody
      Alternate Names
      • Anthrax toxin receptor 1
      • Tumor endothelial marker 8
      Background InformationThe Anthrax toxin receptor 1 (also known as Tumor endothelial marker 8, ANTXR1 and ATR) was initially discovered as the tumor endothelial marker (TEM8). This protein, which exists in three isoforms (33, 37, 41, and 63 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin. Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF). This complex is then endocytosed by the cell; acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK signaling and induce apoptosis.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
      Applications
      ApplicationAnti-ATR Antibody is a highly specific rabbit polyclonal antibody, that targets ATR & has been tested in western blotting, IHC & ICC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      • Immunocytochemistry
      Application NotesImmunohistochemistry Analysis: 2 μg/mL from a representative lot detected ATR in human brain tissue.

      Immunocytochemistry Analysis: 10 μg/mL from a representative lot detected ATR in human brain cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to 13 amino acids near the center region of human ATR.
      EpitopeCenter region
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • ANTXR1
      • ATR
      • TEM8
      Purification MethodPurified by Ion-Exchange Chromatography
      UniProt Number
      Molecular Weight~41 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HepG2 cell lysate.

      Western Blotting Analysis: 2 μg/mL of this antibody detected ATR in HepG2 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications