05-780 | Anti-Akt3/PKBγ Antibody, clone GMA104

05-780
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIP, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-780
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Akt3/PKBγ Antibody, clone GMA104
      References
      Product Information
      FormatPurified
      PresentationBuffered solution containing 0.1M Tris-Glycine, 0.15M NaCl, 0.05% Sodium Azide, pH 7.4.
      Applications
      ApplicationThis Anti-Akt3/PKBγ Antibody, clone GMA104 is validated for use in IP, WB for the detection of Akt3/PKBγ.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      Immunogenpeptide corresponding to amino acids 119-131 (CSPTSQIDNIGEE) of human Akt3/PKBγ
      Cloneclone GMA104
      HostMouse
      SpecificityRhoA
      IsotypeIgG2a
      Species Reactivity
      • Human
      Species Reactivity NotePredicted to cross-react with mouse and rat based on sequence homology.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described.
      Gene Symbol
      • AKT3
      • PRKBG
      • DKFZP434N0250
      • PKBG
      • RAC-gamma
      • RAC-PK-gamma
      • STK-2
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9Y243 # IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival. Capable of phosphorylating several known proteins. Truncated isoform 2/PKB gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent.
      SIZE: 479 amino acids; 55775 Da
      SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell stimulation leading to its translocation.
      TISSUE SPECIFICITY: In adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney.
      DOMAIN:SwissProt: Q9Y243 Binding of the PH domain to the phosphatidylinositol 3- kinase alpha (PI(3)K) results in its targeting to the plasma membrane.
      PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
      SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 PH domain. & Contains 1 protein kinase domain.
      Molecular Weight~60kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on RIPA lysates from Jurkat or HL-60 cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Akt3/PKB#947;, clone GMA104 - DAM1810807 DAM1810807
      Anti-Akt3/PKB, clone GMA104 - JBC1863427 JBC1863427
      Anti-Akt3/PKBg, clone GMA104 (mouse monoclonal IgG2a) - 2005584 2005584
      Anti-Akt3/PKBg, clone GMA104 (mouse monoclonal IgG2a) - 2149484 2149484
      Anti-Akt3/PKBg, clone GMA104 (mouse monoclonal IgG2a) - 2302180 2302180
      Anti-Akt3/PKBg, clone GMA104 - DAM1574324 DAM1574324
      Anti-Akt3/PKBg, clone GMA104 - DAM1739160 DAM1739160
      Anti-Akt3/PKBg, clone GMA104 - DAM1764401 DAM1764401
      Anti-Akt3/PKBg, clone GMA104 - DAM1785848 DAM1785848
      Anti-Akt3/PKBgamma;, clone GMA104 - 26827 26827

      References

      Reference overviewPub Med ID
      The Akt isoforms are present at distinct subcellular locations.
      Santi, SA; Lee, H
      American journal of physiology. Cell physiology  298  C580-91  2010

      Show Abstract
      20018949 20018949
      Characterization of PDK2 activity against protein kinase B gamma.
      Hodgkinson, Conrad P, et al.
      Biochemistry, 41: 10351-9 (2002)  2002

      Show Abstract
      12162751 12162751

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies