MABC276 | Anti-BAG3 Antibody, clone AC-2

MABC276
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABC276
      DescriptionAnti-BAG3 Antibody, clone AC-2
      Alternate Names
      • BAG family molecular chaperone regulator 3
      • Bcl-2-associated athanogene 3
      • Bcl-2-binding protein Bis
      • Docking protein CAIR-1
      Background InformationBcl2-associated athanogene 3 (BAG3), also known as CAIR-1 or Bis, belongs to a family of six evolutionarily conserved co-chaperone proteins that contain a characteristic C-terminal BAG domain. In most cell types, BAG3 is localized to the cytoplasm, where it regulates the heat shock protein 70 chaperone. BAG3 is activated in response to stressful stimuli, and plays a critical role in modulating multiple cellular processes, including apoptosis, autophagy, embryonic development, and actin rearrangement. Abnormal expression of BAG3 results cardiomyopathy dilated type 1HH.
      References
      Product Information
      FormatPurified
      Control
      • HeLa cell lysate
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-BAG3 Antibody, clone AC-2 detects level of BAG3 & has been published & validated for use in Western Blotting.
      Key Applications
      • Western Blotting
      Application NotesImmunoprecipitation Analysis: A 1:500 dilution from a representative lot detected BAG3 IP'd from 500 µg of HeLa lysate.
      Biological Information
      ImmunogenMAP peptide corresponding to human BAG3.
      CloneAC-2
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • BAG3
      • BIS
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~62-80 kDa observed. The calculated molecular weight of this protein is 62 kDa, but can run as high as 80 kDa due to PTM.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HeLa cell lysate.

      Western Blot Analysis: A 1:1000 dilution of this antibody detected BAG3 in 10 µg of HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies