MABN114 | Anti-BDNF Antibody, clone 1G10.2

MABN114
100 μg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN114
      DescriptionAnti-BDNF Antibody, clone 1G10.2
      Alternate Names
      • Brain-derived neurotrophic factor
      • BDNF
      • Abrineurin
      • Neurotrophin
      Background InformationBrain-derived neurotrophic factor (UniProt P23560; also known as Abrineurin, BDNF, Neurotrophin) is encoded by the BDNF (also known as BULN2) gene (Gene ID 627) in human. BDNF is a member of the NGF family of neurotrophic factors (also named neurotrophins) that are required for the differentiation and survival of specific neuronal subpopulations in both the central as well as the peripheral nervous system. The neurotrophin family is comprised of at least four proteins including NGF, BDNF, NT3, and NT4/5. BDNF mediates its neurotrophic properties by signaling through the high affinity cell surface receptor gp145/trkB. BDNF is initially produced with a signal peptide (a.a. 1-18) and a propeptide (a.a. 19-128) sequence, the removal of which yields the mature BDNF (a.a. 129-247).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationDetect BDNF using this Anti-BDNF Antibody, clone 1G10.2 validated for use in Western Blotting, Immunohistochemistry (Paraffin).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected BDNF in human brain, mouse brain, and rat cerebellum tissue sections.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to the C-terminal half of human BDNF.
      EpitopeC-terminal half.
      Clone1G10.2
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 1G10.2 reacts with mature human BDNF. Also expected to react with all five spliced human prepro-BDNF isoforms reported by UniProt (P23560).
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • BDNF
      • BULN2
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~15 kDa observed. 13.51 kDa (mature BDNF), 27.82 kDa (prepro-BDNF isoform 1), 28.87 kDa (prepro-BDNF isoform 2), 29.82 kDa (prepro-BDNF isoform 3), 37.12 kDa (prepro-BDNF isoform 4), 31.12 kDa (prepro-BDNF isoform 5) calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse retinoblastoma Neuro-2a (N2a) cell lysate.

      Western Blotting Analysis: 2.0 µg/mL of this antibody detected BDNF in 10 µg of mouse retinoblastoma Neuro-2a (N2a) cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies