MABN1080 | Anti-CD35, clone EPR6601, Rabbit Monoclonal Antibody

MABN1080
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCRbUnpurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN1080
      DescriptionAnti-CD35, clone EPR6601, Rabbit Monoclonal Antibody
      Alternate Names
      • Complement receptor type 1
      • C3b/C4b receptor
      • CD antigen CD35
      Background InformationComplement receptor type 1, also known as C3b/C4b receptor or CD35, and encoded by the gene name CR1 or C3BR, is a member of the receptors of complement activation (RCA) family. CD35 is a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. CD35 mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in CD35 have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria.
      References
      Product Information
      FormatUnpurified
      PresentationRabbit monoclonal in buffer containing PBS with up to 0.1% sodium azide, 0.05% BSA, and 50% glycerol.
      Applications
      ApplicationPlease note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:100-250 dilution from a representative lot detected CD35 in human kidney tissue.

      Produced in collaboration with Epitomics™
      Biological Information
      ImmunogenSynthetic peptide corresponding to the extracellular domain of human CD35.
      Epitopeextracellular domain
      CloneEPR6601
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      IsotypeIgG
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • CR1
      • C3BR
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~280 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in TF-1 and human tonsil lysates.

      Western Blotting Analysis: A 1:1,000-10,000 dilution of this antibody detected CD35 in TF-1 and human tonsil lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies